Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Concise Synthetic Approaches to Naturally Occurring β-Hydroxypyranochalcones: First Total Synthesis of Purpurenone, Its Derivative, and Praecansone B

  • Wang, Xue (School of Chemical Engineering, Yeungnam University) ;
  • Lee, Yong-Rok (School of Chemical Engineering, Yeungnam University) ;
  • Kim, Sung-Hong (Analysis Research Division, Daegu Center, Korea Basic Science Institute)
  • Received : 2012.05.01
  • Accepted : 2012.05.14
  • Published : 2012.08.20
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Abstract

The total synthesis of biologically interesting ${\beta}$-hydroxypyranochalcones, purpurenone (1), its derivative 2, praecansone B (3), and pongapinone A (4) has been accomplished starting from commercially available 2,4-dihydroxyacetophenone or 6-methoxy-2,4-dihydroxyacetophenone in 3 steps by a convergent strategy through benzopyran formations, O-methylations, and coupling reactions.

Keywords

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