The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Review : Clinical application and efficacy of herbal medicines by modulating cytokines in atopic dermatitis-induced animal model

동물모델에서 cytokine 조율을 통한 한약의 항아토피피부염 효능과 임상적 응용에 대한 고찰

  • Park, Yeong-Chul (GLP Center, Catholic University of Daegu) ;
  • Lim, Jung-Dae (Dept. of Herbal Medicine Resource, Kangwon National University(Dogye Campus)) ;
  • Park, Yong-Ki (Dept. of Herbology, College of Oriental Medicine, Dongguk University) ;
  • Yoon, Mi-Sook (Dept. of Beauty Coordination, Keimyung College) ;
  • Lee, Sun-Dong (Preventive Medicine, School of Oriental Medicine, Sangji University)
  • 박영철 (대구가톨릭대학교 GLP센터) ;
  • 임정대 (강원대학교 생약자원개발학과) ;
  • 박용기 (동국대학교 한의과대학 본초학교실) ;
  • 윤미숙 (계명문화대학 뷰티코디네이션학부) ;
  • 이선동 (상지대학교 한의과대학 예방의학교실)
  • Received : 2012.06.07
  • Accepted : 2012.06.27
  • Published : 2012.07.30
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Abstract

Objectives : There is a pressing need to determine the clinical and scientific validity of herbal therapies for animal model with atopic dermatitis since some differences in systemic cytokine polarization between in animal model and in patients with atopic dermatitis has been reported. New studies for tang, medicinal herb itself or effective ingradients of medicinal herb showing anti-atopic dermatitis effectiveness are reviewed in terms of cytokine regulation. Methods : Those herbal therapies used to treat atopic dermatitis in animal model were introduced and the expression pattern of cytokine and the activity of mast cell were compared in both animal model and patients with atopic dermatitis. Results : In case of atopic dermatitis in human, there is a biphasic pattern of cytokine expression in atopic dermatitis, with acute skin inflammation associated with a predominance of IL-4 and IL-13 expression from Th2 cells, and chronic inflammation associated with increased IL-5 from Th2-cells and IFN-${\gamma}$ from Th1-cells. However, a pattern of cytokine expression in animal model with atopic dermatitis is not matched well to the biphasic pattern of cytokine expression in patients with atopic dermatitis. In addition, a kind of cytokine is different by animal model with atopic dermatitis. These differences would make herbal medicines, showing their effectiveness on atopic dermatitis, difficult to apply to patients with atopic dermatitis. Conclusion : The pattern of local cytokine expression plays an important role in modulating tissue inflammation, and in atopic dermatitis this pattern depends on the acuity or duration of the skin lesion. Thus, in order to develop medicinal herb itself or effective ingradients of medicinal herb showing anti-atopic dermatitis effectiveness, biphasic pattern of cytokine expression should be considered in animal model with atopic dermatitis.

Keywords

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