KSBB Journal

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Evaluation of Anti-diabetic Effect of Biochanin A in C2C12 Myotube

근육세포 배양 계 에서 Biochanin A의 항 당뇨 효능평가

  • Received : 2011.10.26
  • Accepted : 2011.12.14
  • Published : 2012.02.29
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Abstract

In this study, we evaluated the effects of Biochanin A on glucose uptake in C2C12 myotube. We found that Biochanin A significantly stimulated 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose (2-NBDG) uptake in a dose-dependent manner. In addition, AMPK and PPAR-gamma activities were markedly increased by Biochanin A in a dose-dependent manner. However, Akt, an insulin dependent signaling molecule, did not change by Biochanin A. These results suggest that Biochanin A stimulates glucose uptake via AMPK and PPAR-gamma pathways.

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References

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