Clinical and Experimental Reproductive Medicine

  • 제39권1호
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  • Pages.28-32
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  • 2012
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  • 2233-8233(pISSN)
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  • 2233-8241(eISSN)
대한생식의학회 (The Korean Society for Reproductive Medicine)
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Serum biomarkers for predicting pregnancy outcome in women undergoing IVF: human chorionic gonadotropin, progesterone, and inhibin A level at 11 days post-ET

  • Kim, Jee-Hyun (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital) ;
  • Shin, Mi-Sun (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital) ;
  • Yi, Gwang (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital) ;
  • Jee, Byung-Chul (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital) ;
  • Lee, Jung-Ryeol (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital) ;
  • Suh, Chang-Suk (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital) ;
  • Kim, Seok-Hyun (Department of Obstetrics and Gynecology, Seoul National University College of Medicine)
  • 투고 : 2012.02.26
  • 심사 : 2012.03.30
  • 발행 : 2012.03.31
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초록

Objective: This study was performed to assess the prognostic value of serum hCG, progesterone, and inhibin A levels measured at 11 days post-ET for predicting pregnancy outcome in women participating in IVF. Methods: Between May 2005 and April 2008, sera were obtained from 70 infertile women who underwent IVF-ET at 11 days post-ET and stored. HCG, progesterone, and inhibin A levels were measured by commercial enzyme-linked immunosorbent assay kits. The predictive accuracy of hCG, progesterone, and inhibin A levels for establishment of intrauterine pregnancy and ongoing pregnancy was calculated by receiver-operating characteristic curve analysis. Results: For the prediction of intrauterine and ongoing pregnancy, serum hCG was better than progesterone and inhibin A. The predictive performance of progesterone and inhibin A was similar. The serum progesterone and inhibin A levels were significantly correlated each other (r=0.915, p=0.010). Conclusion: A single measurement of the serum hCG level is sufficient to predict pregnancy outcome in IVF-ET patients.

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참고문헌

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피인용 문헌

  1. Role of early serum beta human chorionic gonadotropin measurement in predicting multiple pregnancy and pregnancy wastage in an in vitro ET fertilization cycle vol.6, pp.3, 2012, https://doi.org/10.4103/0974-1208.121425
  2. Predictive value of early serum beta-human chorionic gonadotrophin for the successful outcome in women undergoing in vitro fertilization vol.6, pp.4, 2012, https://doi.org/10.4103/0974-1208.126291
  3. Does First Serum Beta-Human Chorionic Gonadotropin Value Prognosticate the Early Pregnancy Outcome in an In-Vitro Fertilisation Cycle? vol.10, pp.2, 2012, https://doi.org/10.4103/jhrs.jhrs_50_16
  4. Predictive value of serum progesterone level on β -hCG check day in women with previous repeated miscarriages after in vitro fertilization vol.12, pp.7, 2012, https://doi.org/10.1371/journal.pone.0181229
  5. Development of a novel nomogram for predicting ongoing pregnancy after in vitro fertilization and embryo transfer vol.61, pp.6, 2018, https://doi.org/10.5468/ogs.2018.61.6.669
  6. Increased maternal hCG concentrations in early in vitro pregnancy with elevated basal FSH vol.13, pp.9, 2012, https://doi.org/10.1371/journal.pone.0203610