Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)

The Korean Society of Applied Science and Technology (한국응용과학기술학회)
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Effect of Herb Extracts Mixed with Houttuynia Cordata on Antiatopic Dermatitis in DNCB-Induced BALB/c Mouse

DNCB 유도 BALB/c 생쥐에서 어성초 혼합 한방추출물의 항아토피 효과

  • Park, Sang-Oh (Department of Animal Biotechnology, Kangwon National University) ;
  • Park, Byung-Sung (Department of Animal Biotechnology, Kangwon National University) ;
  • Ryu, Chae-Min (Department of Animal Biotechnology, Kangwon National University) ;
  • Ahn, Yong-Sik (Department of Animal Biotechnology, Kangwon National University)
  • 박상오 (강원대학교 동물생명공학과) ;
  • 박병성 (강원대학교 동물생명공학과) ;
  • 류채민 (강원대학교 동물생명공학과) ;
  • 안용식 (강원대학교 동물생명공학과)
  • Received : 2012.03.05
  • Accepted : 2012.06.15
  • Published : 2012.06.30
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Abstract

This study was evaluated the antiatopic activity of cream containing a herb extracts mixed with Houttuynia cordata in DNCB-induced BALB/c atopy mouse. The randomized complete block design was done by BALB/c mouse into two groups, of which the control group with atopy and the cream treatment group. It was found that each level of IgE and histamine in blood was significantly decreased in the cream treatment group, compared with the DNCB-induced atopy control group. When the cream was applied to the atopy mouse, it could be observed that its skin recovered to normal condition with the skin surface being clean and smooth without any horny tissue. The results suggest that the application of herb extracts mixed with Houttuynia cordata has an antiatopic activity through a inhibition of histamin emissions with reducing the levels of blood IgE in BALB/C atopy mouse.

본 연구는 아토피 피부염을 갖는 질환동물에서 어성초를 비롯한 다양한 식물추출물을 이용하여 제조한 크림의 항아토피 피부염증에 대한 효능을 평가하였다. BALB/c 마우스 를 이용하여 아토피 피부염 유발 대조군 및 크림 처리군으로 완전 임의 배치하였다. 혈액 IgE와 히스타민 농도는 크림 처리군이 DNCB 유도 아토피 대조군에 비해서 유의하게 감소하였으며, 아토피 피부염이 심각한 상태의 마우스에서 정상적인 피부상태로 회복되었음을 관찰하였다. 본 결과는 아토피질환 모델 BALB/c 마우스에서 어성초 혼합 식물추출물의 투여가 혈액 IgE를 낮춤과 동시에 비만세포에서 생성되는 히스타민의 배출량을 억제함으로써 항아토피 효능을 갖는다는 점을 시사 해준다.

Keywords

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