한국의 마른 체형 소아에 대한 성장증보탕(成長增補湯)의 체중개선 효과

The Weight Gain Effects of Sungjangjeungbo-tang (Ch$\acute{e}$ngzh$\check{a}$ngz$\bar{e}$ngb$\check{u}$-tang) on Thin Korean Preschool Children

  • 김기준 (서울대학교 식품영양학과) ;
  • 이준석 (BOM 한의학 연구소) ;
  • 윤지현 (서울대학교 식품영양학과) ;
  • 류봉하 (경희대학교 한의과대학 비계내과학교실) ;
  • 백희영 (서울대학교 식품영양학과)
  • Kim, Ki-Joon (Dept. of Food and Nutrition, Seoul National University) ;
  • Lee, Joon-Suk (BOM Research Institute) ;
  • Yoon, Ji-Hyun (Dept. of Food and Nutrition, Seoul National University) ;
  • Ryu, Bong-Ha (3rd Dept. of Internal Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Paik, Hee-Young (Dept. of Food and Nutrition, Seoul National University)
  • 발행 : 2012.06.30

초록

Objectives : The aim of this study was to investigate weight gain effects of the Sungjangjeungbo-tang (Ch$\acute{e}$ngzh$\check{a}$ngz$\bar{e}$ngb$\check{u}$-tang) on thin Korean preschool children. Methods : Sungjangjeungbo-tang is composed of 9 herbs for treating indigestion. We analyzed 119 preschool children who visited Kim Kijoon Oriental Clinic BOM from Jan. 1, 2006 to Aug. 31, 2011 with three criteria: 1) 2~5yrs of age and BMI < 50th percentile on the baseline visit; 2) the child had taken the Sungjangjeungbo-tang for 1~3 month(s); and 3) the clinic had records of both height and weight on the baseline and at least once over 1~3 month(s). Results : Sungjangjeungbo-tang significantly improved BMI percentile in all groups. The changes in BMI percentile variations were larger in the 3 months group than in other groups, but not significantly. Gender, age and BMI on the baseline had no significant effects on the effectiveness of Sungjangjeungbo-tang. Conclusions : Sungjangjeungbo-tang positively affected on weight gain in thin Korean preschool children within 1~3 month(s) of treatment. However, additional studies on functional dyspepsia or the change of energy intake were needed to know the factors related to weight gains.

키워드

참고문헌

  1. World Health Organization Expert Committee on Physical Status. Physical Status: The Use and Interpretation of Anthropometry. World Health Organ Tech Rep Ser 1995;854:1-452.
  2. Kuczmarski RJ, Ogden CL, Guo SS, Grummer-Strawn LM, Flegal KM, Mei Z, et al. 2000 CDC growth charts for the United States: methods and development. Vital Health Stat 2002;(246):1-190.
  3. Tounian P, Dumas C, Veinberg F, Girardet JP. Resting energy expenditure and substrate utilisation rate in children with constitutional leanness or obesity. Clin Nutr 2003;22(4):353-7. https://doi.org/10.1016/S0261-5614(02)00217-0
  4. 이연숙, 임현숙, 안홍석, 장남수. 생애주기영양학. 경기도: 교문사; 2007, p. 207-14.
  5. Pimenta AM, Beunza JJ, Sanchez-Villegas A, Bes-Rastrollo M, Martinez-Gonzalez MA. Childhood underweight, weight gain during childhood to adolescence/young adulthood and incidence of adult metabolic syndrome in the SUN(Seguimiento Universidad de Navarra) Project. Public Health Nutr 2010;17:1-8.
  6. Zheng W, McLerran DF, Rolland B, Zhang X, Inoue M, Matsuo K, et al. Association between Body-Mass Index and Risk of Death in More Than 1 Million Asians. NEJM 2011;364:719-29. https://doi.org/10.1056/NEJMoa1010679
  7. Thakwalakwa C, Ashorn P, Phuka J, Cheung YB, Briend A, Puumalainen T, et al. A lipid-based nutrient supplement but not corn-soy blend modestly increases weight gain among 6-to 18-month-old moderately underweight children in rural Malawi. J Nutr 2010;140(11):2008-13. https://doi.org/10.3945/jn.110.122499
  8. Jilcott SB, Ickes SB, Ammerman AS, Myhre JA. Iterative design, implementation and evaluation of a supplemental feeding program for underweight children ages 6-59 months in Western Uganda. Matern Child Health J 2010;14(2):299-306. https://doi.org/10.1007/s10995-009-0456-3
  9. Maleta K, Kuittinen J, Duggan MB, Briend A, Manary M, Wales J, et al. Supplementary feeding of underweight, stunted Malawian children with a ready-to-use food. J Pediatr Gastroenterol Nutr 2004;38(2):143-5. https://doi.org/10.1097/00005176-200402000-00007
  10. Bekem O, Buyukgebiz B, Aydin A, Ozturk Y, Tasci C, Arslan N, et al. Prokinetic agents in childen with poor appetite. Acta Gastroenterol Belg 2005;68(4):416-8.
  11. Diehl LW. Treatment of underweight and appetite loss with antiallergic agent cyproheptadine. Ther Ggw 1971;110(5):741-2.
  12. Hermans W. Clinical evaluation of buclizine for underweight patients. Brux Med 1971;51(4): 295-8.
  13. Doshi JC, Vaidya A, Gudibanda KK, Gupta KC, Karandikar PV, Sheth UK. Methandienone-an anabolic agent in underweight healthy subjects. Indian J Med Sci 1966;20(10):674-6.
  14. Watson RN, Bradley MH, Callahan R, Peters BJ, Kory RC. A six-month evaluation of an anabolic drug, norethandrolone, in underweight persons. I. Weight gain. Am J Med 1959;26(2): 238-42. https://doi.org/10.1016/0002-9343(59)90312-2
  15. Mulhausen W. The effects of vitamin T Goetsch in underdeveloped and underweight adolescents. Monatsschr Kinderheilkd 1953;101(1):13-4.
  16. 김호철. 한약약리학. 경기도: 집문당; 2008, p. 215, 216, 266, 283, 286, 429, 441.
  17. Khasnutdinova SL, Grjibovski AM. Prevalence of stunting, underweight, overweight and obesity in adolescents in Velsk district, north-west Russia: a cross-sectional study using both international and Russian growth references. Public Health 2010;124(7):392-7. https://doi.org/10.1016/j.puhe.2010.03.017
  18. de Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ 2007; 85(9):660-7. https://doi.org/10.2471/BLT.07.043497
  19. Talley NJ, Quan C, Jones MP, Horowitz M. The association of upper and lower gastrointestinal tract symptoms with body mass index in an Australian cohort. Neurogastro Motil 2004;16: 413-9. https://doi.org/10.1111/j.1365-2982.2004.00530.x
  20. Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J. Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 1998;115(6):1346-52. https://doi.org/10.1016/S0016-5085(98)70012-5
  21. 김종윤, 이진용, 윤상협. 기능성 소화불량증 患兒의 위전도에 대한 內消和中湯의 效果. 대한한방소아과학회지 2002;16(2):199-213.
  22. 이준석, 윤상협, 김진성, 류봉하. 흰쥐의 胃排 出能에 대한 半夏瀉心湯의 效能. 대한한방내과학회지 2006;27(2):471-9.
  23. 윤상협, 류봉하, 류기원, 김진성. 기능성 소화불량증 환자에 대한 반하사심탕 엑기스제의 임상 효과. 대한한방내과학회지 2003;24(2):329-36.
  24. 한숙영, 윤상협, 김진성, 류봉하. 이진탕(二陳 湯)이 정상 및 위 유문부가 부분폐색된 흰 쥐의 위 운동성에 미치는 효과. 대한한방내과학회지 2009;30(1):107-18.
  25. 원종만, 윤상협. 김진성, 류봉하. 육군자탕(六君 子湯)이 흰쥐의 위(胃) 배출능(排出能)에 미치는 영향. 대한한방내과학회지 2007;28(2):242-9.
  26. 김진석, 윤상협. 내소산(內消散)의 정상 및 위 유문부 확장 흰 쥐의 위 운동성에 대한 효능. 대한한방내과학회지 2008;29(1):117-29.
  27. 남효익, 김회영, 손현수, 임성우. 정전가미이진 탕(正傳加味二陳湯)이 흰쥐의 위배출능(胃排 出能)에 미치는 영향. 대한한방내과학회지 2007; 28(2):209-16.