Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
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Effect of Fiber Number Per Mass Concentration in Korean Produced Asbestos on Lung Function and Pathology

중량당 섬유수가 다른 국내산 석면이 폐 기능과 폐 조직에 미치는 영향 평가

  • Chung, Yong Hyun (Toxicological Research Team, Center for Chemicals Safety and Health, Occupational Safety & Health Research Institute) ;
  • Han, Jeong Hee (Toxicological Research Team, Center for Chemicals Safety and Health, Occupational Safety & Health Research Institute) ;
  • Kang, Min Gu (Toxicological Research Team, Center for Chemicals Safety and Health, Occupational Safety & Health Research Institute) ;
  • Kim, Jong Kyu (Toxicological Research Team, Center for Chemicals Safety and Health, Occupational Safety & Health Research Institute) ;
  • Yang, Jeong Sun (Toxicological Research Team, Center for Chemicals Safety and Health, Occupational Safety & Health Research Institute)
  • 정용현 (산업안전보건연구원 화학물질센터 독성연구팀) ;
  • 한정희 (산업안전보건연구원 화학물질센터 독성연구팀) ;
  • 강민구 (산업안전보건연구원 화학물질센터 독성연구팀) ;
  • 김종규 (산업안전보건연구원 화학물질센터 독성연구팀) ;
  • 양정선 (산업안전보건연구원 화학물질센터 독성연구팀)
  • Published : 2012.12.31
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Abstract

Objectives: To evaluate the pulmonary toxicity of 2 Korea asbestos(chrysotile, anthophyllite), Sprague-Dawely rats were exposed to 2 mg domestic asbestos by intratracheal instillation(IT). Methods: Lung function of rats was analyzed by pressure transducer(MAX1320, Buxco Electronics, USA). The effects of 2 mg asbestos(chrysotile ; $8,814,244{\times}10^{6}$ fibers/mg, average diameter 0.08 ${\mu}m$, average length 4.39 ${\mu}m$, anthophyllite ; $5,182{\times}10^{6}$ fibers/mg, average diameter 0.95 ${\mu}m$, average length 7.29 ${\mu}m$) on pulmonary function and pathological changes were evaluated at after a single IT. Lung function and histopathological evaluation were assessed in 5 animals from each group at each time point. Results: Due to differences in fiber numbers, chrysotile induce marked lung pathology and lung function change than anthophyllite at the same mass dose. Chrysotile showed notable thickening of interstitial areas surrounding the alveolar ducts and terminal bronchioles. Conclusions: On a mass dose basis, chrysotile that have 1,700 times numbers of fibers per unit weight than anthophyllite produced a greater persistent lung injury than anthophllite for at least 4 weeks after exposure.

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References

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