Journal of Korean Society on Water Environment (한국물환경학회지)

Korean Society on Water Environment (한국물환경학회)
권호 표지

A Study on the Degradability of Pharmaceuticals during UV Treatment

자외선 처리시의 의약품류의 분해도에 관한 연구

  • Kim, Ilho (Environment Research Division, Water Resources & Environment Research Department, Korea Institute of Construction Technology / Department of Construction Environment Engineering, University of Science & Technology)
  • 김일호 (한국건설기술연구원 수자원환경연구본부 환경연구실.과학기술연합대학원대학교 건설환경공학과)
  • Published : 2012.11.30
⟨ Previous Next ⟩

Abstract

The photodegradation characteristics of 30 pharmaceuticals were investigated by batch experiments using Ultraviolet (UV) reactor. The investigated pharmaceuticals include antibiotics, analgesics and antiarrhythmic agents etc. Tested water was prepared by simultaneously spiking 30 pharmaceuticals into pure water, and each experiment was conducted using 3 types of UV lamps. As a result, batch experiments showed that reactions of all the investigated pharmaceuticals followed pseudo-first order reaction regardless of the applied UV lamps. Among the pharmaceuticals, Cyclophosphamide, 2-Quinoxaline carboxylic acid and Clarithromycin proved to be the most UV-resistant compounds. Contrarily, Ceftiofur, Diclofenac and Ketoprofen were easily degraded by all the UV lamps. Dissolved organic carbon (DOC) concentration hardly changed although the concentration of the pharmaceuticals concentration gradually decreased with time, indicating that the degradation of parent pharmaceuticals may produce their intermediates during UV treatment.

Keywords

References

  1. Antonio, L., Anna, B., Giuseppe, M., and John, K. (2003). Kinetic Investigation on UV and $UV/H_2O_2$ Degradations of Pharmaceutical Intermediates in Aqueous Solution, Journal of Photochemistry and Photobiology, 156, pp. 121-126. https://doi.org/10.1016/S1010-6030(02)00435-5
  2. Arslan, I., Balcioglu, I. A., and Bahnemann, D. W. (2000). Advanced Chemical Oxidation of Reactive Dyes in Simulated Dyehouse Effluents by Ferrioxalate-Fenton/UV-A and $TiO_2/UV-A$ Processes, Dyes and Pigments, 47, pp. 207-218. https://doi.org/10.1016/S0143-7208(00)00082-6
  3. Behera, S. K., Kim, H. W., Oh, J. E., and Park, H. S. (2011). Occurrence and Removal of Antibiotics, Hormones and Several Other Pharmaceuticals in Wastewater Treatment Plants of the Largest Industrial City of Korea, Science of The Total Environment, 409(20), pp. 4351-4360. https://doi.org/10.1016/j.scitotenv.2011.07.015
  4. Benoit, F., Nicklas, P., Roberto, L. G., Antonino, P., and Jeanne, G. (2003). Ecotoxicological Impact of Pharmaceuticals Found in Treated Wastewaters: Study of Carbamazepine, Clofibric Acid and Diclofenac, Ecotoxicology and Environmental Safety, 55, pp. 359-370. https://doi.org/10.1016/S0147-6513(02)00082-9
  5. Gracia-Lor, E., Sancho, J. V., Serrano, R., and Hernandez F. (2012). Occurrence and Removal of Pharmaceuticals in Wastewater Treatment Plants at the Spanish Mediterranean area of Valencia, Chemosphere, 87(5), pp. 453-462. https://doi.org/10.1016/j.chemosphere.2011.12.025
  6. Han, W., Zhu, W., Zhang, P., Zhang, Y., and Li, L. (2004). Photocatalytic Degradation of Phenols in Aqueous Solution Under Irradiation of 254 and 185nm UV light, Catalysis Today, 90, pp. 319-324. https://doi.org/10.1016/j.cattod.2004.04.041
  7. Heberer, T. (2002). Occurrence, fate and Removal of Pharmaceutical Residues in the Aquatic Environment: a Review of Recent Research Data, Toxicology Letters, 131, pp.5-17. https://doi.org/10.1016/S0378-4274(02)00041-3
  8. Huber, M. M., Canonica, S., Park, G. Y., and von Gunten, U. (2003). Oxidation of Pharmaceuticals during Ozonation and Advanced Oxidation Process, Environmental Science & Technology, 37, pp. 1016-1024. https://doi.org/10.1021/es025896h
  9. Huber, M. M. and Ternes T. A. (2005). Oxidation of Pharmaceuticals during Water Treatment with Chlorine Dioxide, Water Research, 39, pp. 3607-3617. https://doi.org/10.1016/j.watres.2005.05.040
  10. Kim, B. S., Kim, Y. S., and Lee, B. H. (2012), Removal of Pharmaceutical Residues on Sewage Treatment Process, Proceedings of Co-Conference of Korean Society on Water Environment and Korean Society of Water and Wastewater, Korean Society on Water Environment and Korean Society of Water and Wastewater, pp. 604-605. [Korean Literature]
  11. Kim, I. H., Ban, H. J., and Kim, S. G. (2012). Removal of Pharmaceuticals in Treated Sewage with Ozone, UV and $H_2O_2,$ Proceedings of Co-Conference of Korean Society on Water Environment and Korean Society of Water and Wastewater, Korean Society on Water Environment and Korean Society of Water and Wastewater, pp. 546-547. [Korean Literature]
  12. Michael, C. (2004). Mixture Toxicity of the Anti-inflammatory Drugs Diclofenac, Ibuprofen, Naproxen, and Acetylsalicylic acid, Ecotoxicology and Environmental Safety, 59, pp. 309-315. https://doi.org/10.1016/S0147-6513(03)00141-6
  13. Nam, S. W, Im, J. K., Kang Y. M., Jo, B. I., Zoh, K. D., and Kim, D. Y. (2012). Occurrence and Removal of Pharmaceuticals in High Turbid Water in Water Treatment Plant, Proceedings of Co-Conference of Korean Society on Water Environment and Korean Society of Water and Wastewater, Korean Society on Water Environment and Korean Society of Water and Wastewater, pp. 464-465. [Korean Literature]
  14. Okuda, T., Yamashita, N., Tanaka, H., Matsukawa, H., and Tanabe, K. (2009). Development of Extraction Method of Pharmaceuticals and Their Occurrences Found in Japanese Wastewater Treatment Plants, Environment International, 35(5), pp. 815-820. https://doi.org/10.1016/j.envint.2009.01.006
  15. Pomati, F., Castiglioni, S., Zuccato, E., Fanelli, R., Vigetti, D., Rossetti, C., and Calamari, D. (2006). Effects of a Complex Mixture of Therapeutic Drugs at Environmental Levels on Human Embryonic cells, Environmental Science & Technology, 40(7), pp. 2442-2447. https://doi.org/10.1021/es051715a
  16. Vogna, D., Marotta, R., Napolitano, A., Andreozzi, R., and d'Ischia, M. (2004). Advanced Oxidation of the Pharmaceutical Drug Diclofenac with $UV/H_2O_2$ and Ozone, Water Research, 38, pp. 414-422. https://doi.org/10.1016/j.watres.2003.09.028
  17. Wei, X., Wang, Z., Fan, F., Wang, J., and Wang, S. (2010). Advanced Treatment of a Complex Pharmaceutical Wastewater by Nanofiltration: Membrane Foulant Identification and Cleaning, Desalination, 251(1-3), pp. 167-175. https://doi.org/10.1016/j.desal.2009.08.005
  18. Zwiener, C. and Frimmel, F. H. (2003). Short-term Tests with a Pilot Sewage Plant and Biofilm Reactors for the Biological Degradation of the Pharmaceutical Compounds Clofibric acid, Ibuprofen, and Diclofenac, The Science of the Total Environment, 309, pp. 201-211. https://doi.org/10.1016/S0048-9697(03)00002-0
  19. 田中信男, 中村昭四郎. (1995). 抗生物質大要第4版, 東京大學出版會, p. 256.