• Title/Summary/Keyword: Pharmaceutical

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Antinociceptive and Sedative Hypnotic effect of Artemisia pallens Wall

  • Karunanidhi, Natesan;Saravanan, Sampath;Vinothkumar, Vinothkumar;Selvamani, Selvamani;Ghosh, Shruti;Gupta, Jayanta Kumar
    • Natural Product Sciences
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    • v.9 no.2
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    • pp.91-92
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    • 2003

  • The present investigation was carried out to evaluate the antinociceptive and sedative - hypnotic effect of a vacuum dried methanol extract of aerial parts of Artemisia pallens. In the tail-flick method with Swiss albino mice the methanol extract at the doses of (1500 mg/kg, 2000 mg/kg, and 2500 mg/kg) showed significant antinociceptive activity. Significant potentiation of Pentobarbitone sodium - induced sleeping time was observed in mice on co-administration of the various doses of the methanol extract of Artemisia pallens.

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Synthesis of 6-Formyl-pyridine-2-carboxylate Derivatives and their Telomerase Inhibitory Activities

  • Jew, Sang-Sup;Park, Boon-Saeng;Lim, Doo-Yeon;Kim, Myoung-Goo;Chung, In-Kwon;Kim, Joo-Hee;Hong, Chung-Il;Kim, Joon-Kyum;Park, Hong-Jun;Lee, Jun-Hee;Park, Hong-Jun;Lee, Jun-Hee;Park, Hyeung-Geun
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.181.4-182
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    • 2003

  • Telomeres are DNA-protein complexes at the ends of chromosomes, which play an essential protective role against DNA degradation and aberrant recombination during cell divisions. Several telomerase inhibitors have been reported as candidates for new antitumor drugs. Among them, 2-thiobenzylpyridines, developed by Geron. Co Ltd. as a telomerase inhibitor, were chosen as lead compounds. Twenty-one pyridine-2- carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. (omitted)

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Synthesis of N-Azaaryl Anilines: An Efficient Protocol via Smiles Rearrangement

  • Xia, Shuai;Wang, Li-Ying;Sun, Heng-Zhi;Yue, Huan;Wang, Xiu-Hua;Tan, Jia-Lian;Wang, Yin;Hou, Di;He, Xiao-Yan;Mun, Ki-Cheol;Kumar, B. Prem;Zuo, Hua;Shin, Dong-Soo
    • Bulletin of the Korean Chemical Society
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    • v.34 no.2
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    • pp.394-398
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    • 2013

  • An efficient process for the synthesis of N-azaaryl anilines via Smiles rearrangement as a tool. A variety of N-azaaryl anilines were generated by the reaction of substituted phenols, substituted anilines, aminopyridines and chloroacetyl chloride or pyridols, under base condition in good to excellent yields.

  • https://doi.org/10.5012/bkcs.2013.34.2.394 인용 PDF KSCI