YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Antibacterial and Antioxidant Activities of the Essential Oil from the Roots of Anthriscus sylvestris

전호(Anthriscus sylvestris) 뿌리 정유의 항균 및 항산화 작용

  • Lim, Hyerim (College of Pharmacy, Duksung Women's University) ;
  • Shin, Seungwon (College of Pharmacy, Duksung Women's University)
  • 임혜림 (덕성여자대학교 약학대학) ;
  • 신승원 (덕성여자대학교 약학대학)
  • Received : 2012.09.25
  • Accepted : 2012.10.08
  • Published : 2012.10.31
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Abstract

To develop a new effective and safe natural antibiotics and antioxidant the essential oil was extracted from the roots of Anthriscus sylvestris by steam distillation. Its composition was analyzed by GC-MS. The activities of the essential oil fraction and its main components were evaluated against antibiotic-susceptible and -resistant strains of some food-born bacteria. In addition the synergism was examined with this oil combined with antibiotic by checkerboard titer test. The antioxidant activities were determined by in 1,1-diphenyl-2-picryl-hydrazil (DPPH) free radical scavenging activity test and reducing power assay. The essential oil fraction of A. sylvestris revealed significant inhibiting activities against antibiotic-susceptible and -resistant species of Vibrio and Shigella with MICs ranged from 1.00~4.00 mg/ml. It showed synergistic or additive effects when it was combined with amphicillin or trimethoprim/sulfamethoxazole (1 : 9). Additionally, the essential oil fraction of A. sylvestris exhibited significant DPPH free radical scavenging activity and the reducing power.

Keywords

Acknowledgement

Supported by : 덕성여자대학교

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