Acknowledgement
본 연구는 (주)한국 얀센의 지원에 의하여 이루어진 것임.
Journal of Korean geriatric psychiatry (노인정신의학)
- Volume 16 Issue 1
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- Pages.24-30
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- 2012
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- 1226-6329(pISSN)
Effects of Galantamine Treatment on Attention, Activities of Daily Living, and Neuropsychiatric Symptoms between the Patients with Pure Alzheimer's Disease and Mixed Dementia
갈란타민(Galantamine) 투여 후 순수 알츠하이머병 치매와 혼합성 치매 환자의 주의력, 일상생활능력 및 신경정신행동 증상에 대한 효과 평가
- Kang, Hyo Shin (Clinical Research Center, Samsung Biomedical Research Institute, Samsung Medical Center) ;
- Yun, Ji Hae (Clinical Research Center, Samsung Biomedical Research Institute, Samsung Medical Center) ;
- Ahn, Inn Sook (Clinical Research Center, Samsung Biomedical Research Institute, Samsung Medical Center) ;
- Moon, Yu Jin (Clinical Research Center, Samsung Biomedical Research Institute, Samsung Medical Center) ;
- Hwang, Tae Young (Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
- Lee, Young Min (Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
- Kim, Hyeran (Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
- Kim, Doh Kwan (Clinical Research Center, Samsung Biomedical Research Institute, Samsung Medical Center)
- 강효신 (삼성서울병원 삼성생명과학연구소 임상의학센터) ;
- 윤지혜 (삼성서울병원 삼성생명과학연구소 임상의학센터) ;
- 안인숙 (삼성서울병원 삼성생명과학연구소 임상의학센터) ;
- 문유진 (삼성서울병원 삼성생명과학연구소 임상의학센터) ;
- 황태영 (성균관대학교 의과대학 삼성서울병원 정신건강의학교실) ;
- 이영민 (성균관대학교 의과대학 삼성서울병원 정신건강의학교실) ;
- 김혜란 (성균관대학교 의과대학 삼성서울병원 정신건강의학교실) ;
- 김도관 (삼성서울병원 삼성생명과학연구소 임상의학센터)
- Received : 2011.12.16
- Accepted : 2012.06.08
- Published : 2012.06.30
Abstract
Objectives : The purpose of this study was to compare the efficacy of galantamine treatment, especially attention ability between patients with pure Alzheimer's disease (AD) and Mixed dementia (MD) during a 24-week trial. Methods : A total of 40 patients were recruited for this 24-week study. The effect of galantamine on attention was measured using Seoul Computerized NeuroCognitive Function Test (SCNT) and frontal functions test of Seoul Neuropsychological Screening Battery (SNSB). Patients'activities of daily living using the Seoul-Activities of Daily Living (S-ADL) and the Seoul-Instrumental Activities of Daily Living (S-IADL) ; behavioral symptoms using the Korean version Neuropsychiatric Inventory (K-NPI) were measured at baseline and 24-week. Results : 17 pure AD patients and 23 MD patients were analyzed in this study. Attention as measured by SCNT was not significantly different from baseline after 24 weeks of treatment in both groups. There was no significant difference between two groups in mean change from baseline in the SCNT, S-ADL, S-IADL and K-NPI scores at 24-week. Conclusion : Galantamine showed a therapeutic effect on cognition, activities of daily living, neuropsychiatric symptoms in pure AD and MD. Furthermore, Galantamine may specifically help to maintain attention and it may have positive effects on other cognitive and functional abilities.
Keywords