Asian Pacific Journal of Cancer Prevention

  • 제13권12호
  • /
  • Pages.6269-6272
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  • 2012
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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SNPs of Excision Repair Cross Complementing Group 5 and Gastric Cancer Risk in Chinese Populations

  • Yang, Wan-Guang (Department of Emergency, the First Affiliated Hospital) ;
  • Zhang, Shan-Feng (School of Basic Medicine, Zhengzhou University) ;
  • Chen, Ju-Wu (Department of Emergency, the First Affiliated Hospital) ;
  • Li, Li (Department of Emergency, the First Affiliated Hospital) ;
  • Wang, Wan-Peng (Department of Emergency, the First Affiliated Hospital) ;
  • Zhang, Xie-Fu (Department of Gastrointestinal Surgery, the First Affiliated Hospital)
  • 발행 : 2012.12.31
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초록

We conducted a case-control study to determine the association between several potential SNPs of excision repair cross complementing group 5 (XPG) and gastric cancer susceptibility, and roles of XPG polymorphisms in combination with H.pylori infection in determining risk of gastric cancer. In our study, we collected 337 newly diagnosed gastric cancer cases and 347 health controls. Three SNPs of XPG, rs2296147T>C, rs2094258C>T and rs873601G>A, were genotyped using the Taqman real-time PCR method with a 7900 HT sequence detector system. H. pylori infection was diagnosed by ELISA. By multivariate logistic regression analysis, the rs2296147 CC genotype was associated with a decreased risk of gastric cancer (OR=0.52, 95% CI=0.27-0.97), and rs2094258 TT was associated with elevated risk (OR=2.13, 95% CI=1.22-3.35). Positive H.pylori individuals with rs2094258 TT genotypes demonstrated increased risk of gastric cancer (OR=2.13, 95% CI=1.22-3.35), while rs2296147 CC was associated with lower risk among patients with negative H.pylori (OR=0.45, 95%CI=0.22-0.89). Our findings suggested that XPG polymorphisms might contribute to risk of gastric cancer among Chinese populations, but the effect needs to be further validated by larger sample size studies.

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  3. The association between XPG polymorphisms and cancer susceptibility vol.96, pp.32, 2017, https://doi.org/10.1097/MD.0000000000007467
  4. Association between the polymorphisms in XPG gene and gastric cancer susceptibility in Chinese populations vol.96, pp.42, 2017, https://doi.org/10.1097/MD.0000000000008213
  5. Association between the XPG gene rs2094258 polymorphism and risk of gastric cancer vol.32, pp.8, 2018, https://doi.org/10.1002/jcla.22564