Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Radiosynthesis and Biodistribution of an 125I-labeled Resveratrol Derivative

  • Kim, Sung-Kew (Department of Oriental Medicine, Kyung Hee University) ;
  • Lee, Woong-San (Department of Chemistry, Korea University) ;
  • Han, Sang-Jin (Department of Molecular Imaging Research, Korea Institute of Radiological and Medical Sciences) ;
  • Kim, Eun-Jung (Department of Molecular Imaging Research, Korea Institute of Radiological and Medical Sciences) ;
  • El-Gamal, Mohammed I. (Center for Biomaterials, Korea Institute of Science and Technology) ;
  • Kim, Byoung-Soo (Department of Molecular Imaging Research, Korea Institute of Radiological and Medical Sciences) ;
  • Choi, Tae-Hyun (Department of Molecular Imaging Research, Korea Institute of Radiological and Medical Sciences) ;
  • Choi, Chang-Woon (Department of Molecular Imaging Research, Korea Institute of Radiological and Medical Sciences) ;
  • Ham, In-Hye (Department of Oriental Medicine, Kyung Hee University) ;
  • Oh, Chang-Hyun (Center for Biomaterials, Korea Institute of Science and Technology) ;
  • Choi, Ho-Young (Department of Oriental Medicine, Kyung Hee University) ;
  • Cho, Jung-Hyuck (Biomolecules Function Research Center, Korea Institute of Science and Technology)
  • Received : 2011.10.31
  • Accepted : 2011.12.06
  • Published : 2012.02.20
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Abstract

An $^{125}I$-labeled resveratrol derivative 1 was synthesized. It was purified by reverse phase HPLC. Radiochemical purity of the product was more than 98%, and the yield was 35% (decay-corrected). Its biodistribution in tumorbearing mice was studied. The results showed that the highest radioactivity was located in intestine and stomach. The biodistribution profile suggests that compound 1 can be effectively used as a promising imaging probe for intestine and stomach.

Keywords

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