Abstract
POEMS syndrome is a monoclonal plasma cell disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. Pulmonary manifestations of POEMS syndrome are common, with frequent symptomatic and asymptomatic respiratory involvement on presentation. However, there have been no reported cases of concomitant sarcoidosis and POEMS syndrome. We treated a 55-year-old woman who presented with dyspnea and bilateral lower leg pitting edema. She had been diagnosed with sarcoidosis 4 years earlier. We reassessed the patient meticulously and found polyneuropathy, IgG lambda type monoclonal gammopathy, lymphadenopathy, hepatosplenomegaly, hypothyroidism, hypertrichosis, and pleural and pericardial effusions, all of which led us to diagnose POEMS syndrome. Immunosuppression with high-dose dexamethasone led to clinical and radiological improvement.
POEMS 증후군은 다발성신경병증(polyneuropathy), 장기종대(organomegaly), 다양한 형태의 내분비장애(endocrinopathy), 단클론성 감마글로블린병증(monoclonal gammopahty), 피부병변(skin lesion)을 특징으로 하는 드문 질환으로, 폐침범의 형태로 유육종증을 동반한 예는 보고된 바가 없다. 저자들은 유육종증(sarcoidosis)을 동반한 POEMS 증후군 환자를 경험하였기에 보고하는 바이다.