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임산부에서 발생한 원발성 폐암 1예

A 36 Year-Old Primivida Diagnosed with Primary Lung Cancer

  • 고선혜 (가톨릭대학교 의과대학 내과학교실) ;
  • 강현희 (가톨릭대학교 의과대학 내과학교실) ;
  • 임선미 (가톨릭대학교 의과대학 내과학교실) ;
  • 황유미 (가톨릭대학교 의과대학 내과학교실) ;
  • 지은혜 (가톨릭대학교 의과대학 내과학교실) ;
  • 오유석 (가톨릭대학교 의과대학 내과학교실) ;
  • 이상학 (가톨릭대학교 의과대학 내과학교실)
  • Ko, Sun-Hye (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Kang, Hyeon-Hui (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Yim, Sun-Mie (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Hwang, You-Mi (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Ji, Eun-Hye (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Oh, You-Suk (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Lee, Sang-Haak (Department of Internal Medicine, The Catholic University of Korea College of Medicine)
  • 발행 : 2012.01.01

초록

흡연의 과거력이 없는 36세 임신 29주 초임부가 3일간 지속된 기침을 주소로 내원했다. 흉부 엑스선상 우상엽의 무기폐가 관찰되었고 흉부전산화단층 촬영에서 우상엽에 7.5 cm의 종괴와 이로 인한 무기폐 소견이 관찰되었다. 경기관지폐생검상 원발성 선암으로 진단했으며 임상적 병기는 4기였다. 환자는 임신 중 항암 치료에 대해 완강히 거부하여, 산부인과 및 소아과와 협진하여 임신 34주에 제왕절개술을 시행하고, 그 이후 항암 치료를 계획하였으나 임신 30주에 저산소증 소견을 보이고 태아곤란 현상이 관찰되어 응급제왕절개술로 출산하였다. 출산 후 뇌전이에 대한 방사선 치료 및 cisplatin-pemetrexed 복합화학요법을 시행하였으나 점차적으로 악화되어 진단 95일 만에 사망하였다. 임신한 여성에서 발생하는 폐암은 매우 드물며 의료진은 치료 방법의 결정을 위해 산모와 태아에 대한 윤리적 고찰을 시행함과 동시에 다학제적인 접근을 통해 환자와 상의하여야 한다. 저자들은 36세 초임부에서 발생한 폐암 1예를 경험하였기에 이를 문헌고찰과 함께 보고하는 바이다.

A 36-year-old primivida, at 29 weeks of pregnancy with no smoking history, was admitted to the hospital complaining of cough for 3 days. Chest X-rays revealed atelectasis of the right upper lobe, and a transbronchial lung biopsy confirmed primary lung adenocarcinoma. After consulting with obstetricians and neonatologists, we wanted to deliver the child and treat the mother with chemoradiotherapy. But as she was adamantly opposed to treatment until fetal lung maturation was complete, we planned to delay the birth until 34 weeks, deliver the baby by caesarian section, and then treat the mother. However, maternal hypoxia and fetal distress resulted in an emergency delivery at 30 weeks. After delivery, we treated the mother's brain metastases with radiation therapy and systemic cisplatin-pemetrexed, but she deteriorated and expired 95 days after the diagnosis. Lung cancer during pregnancy is a rare disease and raises many medical and ethical issues in deciding the best course of therapy. We describe our clinical approach and review the potentially challenging features of managing a pregnant patient with lung cancer.

키워드

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