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A Case of Long-Segment Barrett's Esophagus with Mixed Connective Tissue Disease

복합 교원성 질환 환자에서 발생한 장분절 바렛식도 1예

  • Mun, Jun-Il (Department of Gastroenterology, Ajou University School of Medicine) ;
  • Kim, Dong-Hoon (Department of Gastroenterology, Ajou University School of Medicine) ;
  • Koo, Jee-Hoon (Department of Gastroenterology, Ajou University School of Medicine) ;
  • Kim, In-Sung (Department of Gastroenterology, Ajou University School of Medicine) ;
  • Lee, Kwang-Jae (Department of Gastroenterology, Ajou University School of Medicine)
  • 문준일 (아주대학교 의과대학 소화기내과학교실) ;
  • 김동훈 (아주대학교 의과대학 소화기내과학교실) ;
  • 구지훈 (아주대학교 의과대학 소화기내과학교실) ;
  • 김인성 (아주대학교 의과대학 소화기내과학교실) ;
  • 이광재 (아주대학교 의과대학 소화기내과학교실)
  • Published : 2012.01.01

Abstract

Barrett's esophagus is a metaplasia of the esophageal epithelium of any length, such that normal squamous epithelium is replaced by specialized columnar epithelium with goblet cells. It is important to diagnose and survey Barrett's esophagus because it is believed to be the major risk factor for development of esophageal adenocarcinoma. However, the prevalence of Barrett's esophagus in Korea is low. Mixed connective tissue disease (MCTD) is a systemic disorder in which patients have combinations of the clinical features of systemic lupus erythematosus, systemic sclerosis, and polymyositis. Although gastroesophageal reflux disease is common in esophageal involvement in MCTD, long-segment Barrett's esophagus in MCTD has not been reported in Korea. We report here a 15 cm-long segment of Barrett's esophagus extending to the proximal esophagus in a female patient who has had MCTD for 2 years, and we review the literature.

바렛식도는 정상 식도편평상피가 배세포를 동반한 특수원주상피로 이형성 된 것을 말한다. 바렛식도는 식도 선암의 발생에 있어 가장 중요한 위험요인으로 정확한 진단 및 주기적 감시가 중요하다. 그러나 한국에서의 바렛식도 유병률은 아직까지 높지 않고 이에 대한 연구가 부족한 현실이다. 복합교원성 질환은 전신성 홍반성 루푸스, 전신성 경화증 및 다발성 근염의 임상증상을 함께 가지는 전신 질환이다. 복합교원성 질환에서 위식도 역류증은 흔한 것으로 알려져 있으나 본 증례와 같이 장분절 바렛식도가 동반된 보고는 한국에서 없었다. 저자들은 복합교원성 질환과 함께 근위부 식도까지 연결되어 있는 15 cm 정도의 긴 장분절 바렛식도를 가지고 있는 여성 환자를 경험하고 2년 동안 추적관찰하여 문헌 고찰과 함께 보고하는 바이다.

Keywords

References

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