The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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A Case of Kounis Syndrome Induced by a Non-Steroidal Anti-Inflammatory Drug

비스테로이드성 항염증약물에 의해 발생한 Kounis 증후군 1예

  • Choi, Eun-Jeong (Department of Internal Medicine, Hallym University College of Medicine) ;
  • Shin, Yun-Ho (Department of Internal Medicine, Hallym University College of Medicine) ;
  • Na, Dong-Kil (Department of Internal Medicine, Hallym University College of Medicine) ;
  • Kim, Ji-Hyun (Department of Internal Medicine, Hallym University College of Medicine) ;
  • Choi, Seong-Hoon (Department of Internal Medicine, Hallym University College of Medicine) ;
  • Cho, Jung-Rae (Department of Internal Medicine, Hallym University College of Medicine) ;
  • Lee, Nam-Ho (Department of Internal Medicine, Hallym University College of Medicine)
  • 최은정 (한림대학교 의과대학 내과학교실) ;
  • 신윤호 (한림대학교 의과대학 내과학교실) ;
  • 나동길 (한림대학교 의과대학 내과학교실) ;
  • 김지현 (한림대학교 의과대학 내과학교실) ;
  • 최성훈 (한림대학교 의과대학 내과학교실) ;
  • 조정래 (한림대학교 의과대학 내과학교실) ;
  • 이남호 (한림대학교 의과대학 내과학교실)
  • Published : 2012.06.01
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Abstract

In 1991, Kounis and Zavras described the "syndrome of allergic angina" as the coincidental occurrence of angina and allergic reactions by inflammatory mediators released during the allergic insult. Presently, both allergic angina and allergic myocardial infarction are referred to as "Kounis syndrome." Several allergens, including drugs, Hymenoptera venom, latex, food, and contrast media have been reported to trigger Kounis syndrome. Three variants of this syndrome have been described. Type I includes patients with normal coronary arteries, Type II includes patients with preexisting atheromatous disease where acute release of inflammatory mediators can induce coronary artery spasms, and Type III is associated with intracoronary thrombus formation caused by an allergic reaction. We report a case of Kounis syndrome who presented as acute myocardial infarction after intramuscular injection of a non-steroidal anti-inflammatory drug.

본 증례는 관상동맥경화증의 위험인자나 관상동맥 질환의 병력이 없던 젊은 연령의 환자에서 약물에 대한 알레르기 반응에 의해 급성심근경색증이 발생한 Kounis 증후군으로 추정되어 보고하는 바이다.

Keywords

References

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