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Association Between XPD Asp312Asn Polymorphism and Esophageal Cancer Susceptibility: A Meta-analysis

  • Duan, Xiao-Li (Department of Digestion Medicine, Taihe Hospital, Hubei University of Medicine) ;
  • Gong, Heng (Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine) ;
  • Zeng, Xian-Tao (Department of Stomatology, Taihe Hospital, Hubei University of Medicine) ;
  • Ni, Xiao-Bing (Department of Stomatology, Taihe Hospital, Hubei University of Medicine) ;
  • Yan, Yan (Department of Stomatology, Taihe Hospital, Hubei University of Medicine) ;
  • Chen, Wen (Department of Medical Imaging, Taihe Hospital, Hubei University of Medicine) ;
  • Liu, Guo-Lei (Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine)
  • 발행 : 2012.07.31

초록

Objective: To investigate the association between xeroderma pigmentosum group D (XPD) Asp312Asn polymorphism and esophageal cancer (EC) susceptibility by meta-analysis. Methods: We searched PubMed up to April 9th, 2012, to identify relevant papers, and 8 published case-control studies including 2165 EC patients and 3141 healthy controls were yielded. Odds ratios (ORs) with relevant 95% confidence intervals (CIs) were applied to assess the association between XPD Asp312Asn polymorphism and EC susceptibility with the Comprehensive Meta-Analysis software, version 2.2. Results: Overall, the meta-analysis results suggested the XPD Asp312Asn polymorphism to be significantly associated with EC susceptibility [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.20, 95%CI=1.05-1.36, p=0.01; and Asp/Asn vs. Asp/Asp: OR=1.15, 95%CI =1.01-1.31, p=0.04]. In the subgroup analysis by ethnicity and cancer type, significantly associations were found for Caucasian populations [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.26, 95%CI =1.08-1.47, p<0.001; Asp/Asn vs. Asp/Asp: OR=1.19, 95%CI =1.02-1.40, p=0.03] and esophageal squamous cell carcinoma [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.19, 95%CI=1.01-1.41, p=0.04]. There was no heterogeneity and no publication bias existed. Conclusions: This meta-analysis shows that the XPD Asp312Asn polymorphism may be a risk factor for developing EC, especially for Caucasian populations and esophageal squamous cell carcinoma.

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참고문헌

  1. Borenstein M, Hedges L, Rothstein H (2005) Comprehensive Meta-analysis. Version 2 ed. Biostat, Englewood, New Jersey.
  2. Brown LM, Devesa SS, Chow WH (2008). Incidence of adenocarcinoma of the esophagus among white Americans by sex, stage, and age. J Natl Cancer Inst, 100, 1184-7. https://doi.org/10.1093/jnci/djn211
  3. Cleaver JE, Thompson LH, Richardson AS, et al (1999). A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. Hum Mutat, 14, 9-22. https://doi.org/10.1002/(SICI)1098-1004(1999)14:1<9::AID-HUMU2>3.0.CO;2-6
  4. Coin F, Marinoni JC, Rodolfo C, et al (1998). Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH. Nat Genet, 20, 184-8. https://doi.org/10.1038/2491
  5. Ding DP, Ma WL, He XF, et al (2012). XPD Lys751Gln polymorphism and esophageal cancer susceptibility: a meta-analysis of case-control studies. Mol Biol Rep, 39, 2533-40. https://doi.org/10.1007/s11033-011-1005-x
  6. Egger M, Davey Smith G, Schneider M, et al (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
  7. Higgins JP, Thompson SG (2002). Quantifying heterogeneity in a meta-analysis. Stat Med, 21, 1539-58. https://doi.org/10.1002/sim.1186
  8. Higgins JP, Thompson SG, Deeks JJ, et al (2003). Measuring inconsistency in meta-analyses. BMJ, 327, 557-60. https://doi.org/10.1136/bmj.327.7414.557
  9. Hoeijmakers JH (2001). Genome maintenance mechanisms for preventing cancer. Nature, 411, 366-74. https://doi.org/10.1038/35077232
  10. Huang CG, Liu T, Lv GD, et al (2012). Analysis of XPD genetic polymorphisms of esophageal squamous cell carcinoma in a population of Yili Prefecture, in Xinjiang, China. Mol Biol Rep, 39, 709-14. https://doi.org/10.1007/s11033-011-0789-z
  11. Lea IA, Jackson MA, Li X, et al (2007). Genetic pathways and mutation profiles of human cancers: site- and exposure-specific patterns. Carcinogenesis, 28, 1851-8. https://doi.org/10.1093/carcin/bgm176
  12. Liu G, Zhou W, Yeap BY, et al (2007). XRCC1 and XPD polymorphisms and esophageal adenocarcinoma risk. Carcinogenesis, 28, 1254-8. https://doi.org/10.1093/carcin/bgm020
  13. Mayne ST, Risch HA, Dubrow R, et al (2001). Nutrient intake and risk of subtypes of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prev, 10, 1055-62.
  14. Moher D, Liberati A, Tetzlaff J, et al (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ, 339, b2535. https://doi.org/10.1136/bmj.b2535
  15. Pan J, Lin J, Izzo JG, et al (2009). Genetic susceptibility to esophageal cancer: the role of the nucleotide excision repair pathway. Carcinogenesis, 30, 785-92. https://doi.org/10.1093/carcin/bgp058
  16. Shen MR, Jones IM, Mohrenweiser H (1998). Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. Cancer Res, 58, 604-8.
  17. Szumilo J (2009). Epidemiology and risk factors of the esophageal squamous cell carcinoma. Pol Merkur Lekarski, 26, 82-5.
  18. Tse D, Zhai R, Zhou W, et al (2008). Polymorphisms of the NER pathway genes, ERCC1 and XPD are associated with esophageal adenocarcinoma risk. Cancer Causes Control, 19, 1077-83. https://doi.org/10.1007/s10552-008-9171-4
  19. Umar SB, Fleischer DE (2008). Esophageal cancer: epidemiology, pathogenesis and prevention. Nat Clin Pract Gastroenterol Hepatol, 5, 517-26. https://doi.org/10.1038/ncpgasthep1223
  20. Vaughan TL, Davis S, Kristal A, et al (1995). Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev, 4, 85-92.
  21. Wood RD, Mitchell M, Sgouros J, et al (2001). Human DNA repair genes. Science, 291, 1284-9. https://doi.org/10.1126/science.1056154
  22. Xing D, Qi J, Miao X, et al (2002). Polymorphisms of DNA repair genes XRCC1 and XPD and their associations with risk of esophageal squamous cell carcinoma in a Chinese population. Int J Cancer, 100, 600-5. https://doi.org/10.1002/ijc.10528
  23. Xing DY, Qi J, Tan W, et al (2003). Association of genetic polymorphisms in the DNA repair gene XPD with risk of lung and esophageal cancer in a Chinese population in Beijing. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 20, 35-8.
  24. Xu XC (2009). Risk factors and gene expression in esophageal cancer. Methods Mol Biol, 471, 335-60. https://doi.org/10.1007/978-1-59745-416-2_17
  25. Ye W, Kumar R, Bacova G, et al (2006). The XPD 751Gln allele is associated with an increased risk for esophageal adenocarcinoma: a population-based case-control study in Sweden. Carcinogenesis, 27, 1835-41. https://doi.org/10.1093/carcin/bgl017
  26. Yu HP, Wang XL, Sun X, et al (2004). Polymorphisms in the DNA repair gene XPD and susceptibility to esophageal squamous cell carcinoma. Cancer Genet Cytogenet, 154, 10-5. https://doi.org/10.1016/j.cancergencyto.2004.01.027
  27. Yuan L, Cui D, Zhao EJ, et al (2011). XPD Lys751Gln polymorphism and esophageal cancer risk: a meta-analysis involving 2288 cases and 4096 controls. World J Gastroenterol, 17, 2343-8. https://doi.org/10.3748/wjg.v17.i18.2343
  28. Zheng S, Vuitton L, Sheyhidin I, et al (2010). Northwestern China: a place to learn more on oesophageal cancer. Part one: behavioural and environmental risk factors. Eur J Gastroenterol Hepatol, 22, 917-25. https://doi.org/10.1097/MEG.0b013e3283313d8b

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