• Title/Summary/Keyword: XPD

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Common Variations of DNA Repair Genes are Associated with Response to Platinum-based Chemotherapy in NSCLCs

  • Li, Xian-Dong;Han, Ji-Chang;Zhang, Yi-Jie;Li, Hong-Bing;Wu, Xue-Yan
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.1
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    • pp.145-148
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    • 2013
  • Aim: Individual differences in chemosensitivity and clinical outcome of non-small-cell lung cancer (NSCLC) patients may be induced by host inherited factors. We investigated the impact of XPD Arg156Arg, XPD Asp312Asn, XPD Asp711Asp and XPD Lys751Gln gene polymorphisms on the efficacy of platinum-based chemotherapy in NSCLC patients. Methods: A total of 496 were consecutively selected from the Affiliated Hospital of Nantong University between Jan. 2003 and Nov. 2006, and all patients were followed-up until Nov. 2011. The genotyping of XPD Arg156Arg, XPD Asp312Asn, XPD Asp711Asp and XPD Lys751Gln was conducted by duplex polymerase-chain-reaction with the confronting-two-pair primer methods. Results: Individuals with XPD 312 C/T+T/T and XPD 711 C/T+T/T exhibited poor responses to chemotherapy when compared with the wild-type genotype, with adjusted ORs(95% CI) of 0.67(0.38-0.97) and 0.54(0.35-0.96), respectively. Cox regression showed the median PFS and OS of patients of XPD 312 C/T+T/T genotype and XPD 711 C/T+T/T genotype to be significantly lower than those with wild-type homozygous genotype. Conclusion: We found polymorphisms in XPD to be associated with response to platinum-based chemotherapy in NSCLC, and our findings provide information for therapeutic decisions for individualized therapy.

Association of XPD and XRCC1 Genetic Polymorphisms with Hepatocellular Carcinoma Risk

  • Guo, Lian-Yi;Jin, Xu-Peng;Niu, Wei;Li, Xiao-Fei;Liu, Bao-Hai;Wang, Yu-Lin
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.9
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    • pp.4423-4426
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    • 2012
  • Aim: XRCC1 and XPD are two major repair genes involved in nucleotide excision repair (NER), which is reported to be associated with risk of several cancers. We explored the association of XRCC1 and XPD polymorphisms with the risk of HCC. Methods: A total of 410 cases with HCC and 410 health controls were collected. XRCC1 Arg194Trp, XRCC1 Arg399Gln, XPD Lys751Gln and XPD Asp312Asn genotyping was performed by duplex polymerase-chain-reaction with the confronting-two-pair primer (PCR-CTPP) method. Results: XRCC1 194Trp/Trp was strongly significantly associated with an increased risk of HCC cancer when compared with the wide-type genotype (OR=2.26, 95% CI=(1.23-5.38). Individuals carrying the XRCC1 399Gln/Gln showed increased risk of HCC (OR=1.74, 95%CI=1.06-2.74). The XPD 751Gln/Gln and Gln allele genotype were associated with strong elevated susceptibility to HCC (OR=3.51 and 1.42, respectively). Conclusion: These results suggest that polymorphisms in XRCC1 and XPD may have functional significance in risk of HCC.

Implication of Polymorphisms in DNA Repair Genes in Prognosis of Hepatocellular Carcinoma

  • Yue, Ai-Min;Xie, Zhen-Bin;Guo, Shu-Ping;Wei, Qi-Dong;Yang, Xiao-Wei
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.1
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    • pp.355-358
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    • 2013
  • XRCC1 genetic polymorphisms could be associated with increased risk of various cancer, including hepatocellular carcinoma (HCC), the fifth most common cancer. We here conducted a study to explore the role of selective SNPs of the XRCC1 and XPD genes in the prognosis of HCC. A total of 231 cases were collected, and genotyping of XRCC1 Arg194Trp, XRCC1 Arg399Gln, XPD Lys751Gln and XPD Asp312Asn was performed by duplex polymerase-chain-reaction with the confronting-two-pair primer method. Our findings indicated XRCC1 399Gln/Gln genotype was associated with a significant difference in the median survival time compared with patients carrying Arg/Trp and Arg/Arg genotypes, and individuals with XPD 751 Gln/ Gln genotype had a significantly greater survival time than patients carrying Lys/Lys and Lys/Gln genotypes. The Cox's regression analysis showed individuals carrying XRCC1 399Trp/Trp genotype had 0.55 fold risk of death from HCC than Arg/Arg genotype. Similarly, XPD 751Gln/Gln had a strong decreasein comparison to XPD Lys/Lys carriers with an HR of 0.34. These results suggest that polymorphisms in XRCC1 and XPD may have functional significance in the prognosis of HCC.

DNA Repair Gene ERCC1 and XPD Polymorphisms Predict Glioma Susceptibility and Prognosis

  • Chen, Da-Qing;Yao, Dong-Xiao;Zhao, Hong-Yang;Yang, Shu-Juan
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.6
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    • pp.2791-2794
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    • 2012
  • Aims: We conducted a case-control study in a Chinese population to clarify the association between polymorphisms in ERCC1 and XPD and susceptibility and survival of glioma. Methods: A total of 393 cases and 410 controls were selected from March 2007 to December 2011. Genotyping of ERCC1 and XPD was conducted by TaqMan assays using the ABI Prism 7911HT Sequence Detection System. All analyses were performed using the STATA statistical package. Results: Polymorphisms in ERCC1 118C/T, ERCC1 8092C/A and XPD Asp312Asn showed no statistically significant difference between glioma cases and controls. However, individuals with the XPD 751Gln/Gln genotype had an increased risk of developing glioma compared with those with the Lys/Lys genotype (adjusted OR=1.64, 95% CI: 1.06-2.89). The ERCC1 118T/T genotype was associated with significantly higher median survival than the ERCC1 C/C genotype (HR=0.67, 95%CI=0.35-0.96). In addition, individuals with XPD 751Gln/Gln had a lower median survival time than XPD Lys/Lys carriers (HR=0.54, 95%CI=0.37-0.93). Conclusion: In conclusion, we observed that the XPD 751Gln/Gln genotype is associated with glioma susceptibility, and ERCC1 118 T/T and XPD 751Gln/Gln genotypes confer a significantly better prognosis.

Association Between Polymorphisms of XRCC1 Arg399Gln and XPD Lys751Gln Genes and Prognosis of Colorectal Cancer in a Chinese Population

  • Gan, Yi;Li, Xiao-Rong;Chen, Dao-Jin;Wu, Jun-Hui
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.11
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    • pp.5721-5724
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    • 2012
  • We conducted this study to detect associations between XRCC1 Arg399Gln and XPD Lys751Gln genotypes and survival of colorectal cancer patients treated with 5-FU/oxalipatin chemotherapy. We included 289 Chinese patients with advanced colorectal cancer, who had received 5-FU/oxalipatin chemotherapy as first-line treatment from January 2005 to January 2007. All patients were followed up till Nov. 2011. Genotyping for XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms was based upon duplex polymerase-chain-reaction with the PCR-RFLP method. In our study, we found the XRCC1 399 Gln/Gln genotype to confer significantly higher rates of response to chemotherapy when compared to the Arg/Arg genotype [OR (95% CI)= 2.56(1.57-2.55)]. patients with the XPD 751 Gln/Gln genotype had significantly higher rates of response to chemotherapy [OR (95% CI)= 1.54(0.87-2.65)] and those with the XRCC1 399 Gln/Gln genotype had a longer average survival time and significantly lower risk of death than did those with the Arg/Arg genotype [HR (95% CI)= 0.66(0.36-0.95)]. Similarly, those carrying the XPD 751Gln/Gln genotype had 0.51-fold the risk of death of those with XPD 751Lys/Lys [HR (95% CI)= 0.51(0.33 -0.94)]. In conclusion, it is suggested that the XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms should be routinely assessed to determine colorectal patients who are more likely to benefit from 5-FU/oxalipatin chemotherapy.

ANALYSIS ON THE INFLUENCE OF XPD IN DUAL-POLARIZED TRANSMISSION

  • Park, Durk-Jong;Ahn, Sang-Il
    • Proceedings of the KSRS Conference
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    • v.2
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    • pp.784-787
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    • 2006
  • Dual-polarized transmission is one of the effective methods to transmit such a high speed data thanks to two independent channel leads to the orthogonal feature between RHCP (Right-Hand Circular Polarization) and LHCP (Left-Hand Circular Polarization). However, in practical case, the transmitted signal by RHCP polarized antenna in satellite can be occurred at the output port of LHCP polarized antenna in ground station, vice versa. XPD (Cross-Polarization Discrimination) is the ratio of the signal level at the output of a receiving antenna that is nominally co-polarized to the transmitting antenna to the output of a receiving antenna of the same gain but nominally orthogonally polarized to the transmitting antenna. In this paper, the detailed estimation of XPD within the interface between satellite and ground station is written and the influence of XPD to link performance is also described.

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Performance Evaluation and Theoretical Model for the Polarization Diversity using Circularly Polarized Waves in N-LOS Radio Environments (비가시거리 전파환경에서 원형편파를 이용한 편파다이버시티의 이론적 모델 및 성능평가)

  • 이주현;하덕호;박정훈
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.14 no.2
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    • pp.133-138
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    • 2003
  • In this paper, we analyzed a two-branch polarization diversity at a mobile station in NLOS environment when a base station transmits a circularly polarized wave. In order to calculate the correlation coefficient considering the XPD(cross polarization discrimination) between the received signals for the two diversity branches, a simple theoretical model of circular polarization diversity is adopted. From the analysis results, it can be seen that the XPD of circularly polarized wave is less than vertically polarized wave about 6~7 dB in measurement results. And also, it is clearly seen that the correlation coefficient of circular polarization diversity evaluated by the XPD is less than that of vertical polarization diversity.

Predictive Role of ERCC1 and XPD Genetic Polymorphisms in Survival of Chinese Non-small Cell Lung Cancer Patients Receiving Chemotherapy

  • Zhang, Zhen-Yong;Tian, Xin;Wu, Rong;Liang, Yuan;Jin, Xue-Ying
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.6
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    • pp.2583-2586
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    • 2012
  • Aim: There is increasing evidence that ERCC1 and XPD have roles in response to chemotherapy among patients with NSCLC, but the results are conflicting. Therefore, we conducted the present prospective study in a Chinese population. Methods: A total of 632 primary NSCLC patients were included, followed-up from May 2006 to May 2011. Polymorphisms were detected by real time PCR with TaqMan probse, using genomic DNA extracted from peripheral blood samples. The Cox regression model was used to analyze the hazard ratios (HR) for ERCC1 and XPD. Results: The median time of follow-up was 31.6 months. Our results showed the ERCC1 118 T/T(HR=1.65, 95% CI=1.17-2.43) and XPD 751 Gln/Gln genotypes (HR=1.52, 95%CI=1.04-2.08) were associated with an increased risk of death from NSCLC. Moreover, the ERCC118 T allele and XPD 751 Gln allele genotypes had a more higher risk of death from NSCLC among both ex-smokers and current smokers. Conclusion: In summary, ERCC1 and XPD gene polymorphisms might provide better prognostic predictive information for NSCLC patients in Chinese populations, with smoking possibly interacting with the genotypes.

Analysis on the XPD Effect in X-Band Dual-Polarization Transmission System (X-Band 이중편파 전송 시스템에서 XPD 영향 분석)

  • Park, Durk-Jong;Ahn, Sang-Il
    • Aerospace Engineering and Technology
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    • v.6 no.2
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    • pp.211-218
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    • 2007
  • Dual-polarization means to use two orthogonal polarizations, namely two independent channels in communication. This can be used to deal with high datarate caused by large amount of observed data in future LEO satellite. However, when two orthogonal polarizations are not perfectly independent to each other in practical, interference is probably raised in each channel, meaning that noise level in passband increases. XPD (Cross-Polarization Discrimination) is the ratio of the signal level at the output of a receiving antenna that is nominally co-polarized to the transmitting antenna to the output of a receiving antenna of the same gain but nominally orthogonal polarized to the transmitting antenna. In this paper, the influence of XPD on the communication between satellite and ground station was analyzed under the assumption that X-Band dual-polarization was applied to KOMPSAT-2 (KOrea Multi-Purpose SATellite-2). Through analysis, it was shown that more than 3dB of link margin was still achievable despite of worst axial ratio, 2.5dB, at ground station antenna when axial ratio of satellite antenna was about 0.5dB under 99% of environmental availability.

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Interaction of XRCC1 and XPD Gene Polymorphisms with Lifestyle and Environmental Factors Regarding Susceptibility to Lung Cancer in a High Incidence Population in North East India

  • Saikia, Bhaskar Jyoti;Phukan, Rup Kumar;Sharma, Santanu Kumar;Sekhon, Gaganpreet Singh;Mahanta, Jagadish
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.5
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    • pp.1993-1999
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    • 2014
  • Background: This study aimed to explore the role of XRCC1 (Arg399Gln) and XPD (Lys751Gln) gene polymorphisms, lifestyle and environmental factors as well as their possible interactions in propensity to develop lung cancer in a population with high incidence from North East India. Materials and Methods: A total of 272 lung cancer cases and 544 controls were collected and XRCC1 (Arg399Gln) and XPD (Lys751Gln) genotypes were analyzed using a polymerase chain reaction based restriction fragment length polymorphism assay. Conditional multiple logistic regression analysis was used to calculate adjusted odds ratios and 95% confidence intervals after adjusting for confounding factors. Results: The combined Gln/Gln genotype of XRCC1 and XPD genes (OR=2.78, CI=1.05-7.38; p=0.040) was significantly associated with increased risk for lung cancer. Interaction of XRCC1Gln/Gln genotype with exposure of wood combustion (OR=2.56, CI=1.16-5.66; p=0.020), exposure of cooking oil fumes (OR=3.45, CI=1.39-8.58; p=0.008) and tobacco smoking (OR=2.54, CI=1.21-5.32; p=0.014) and interaction of XPD with betel quid chewing (OR=2.31, CI=1.23-4.32; p=0.009) and tobacco smoking (OR=2.13, CI=1.12-4.05; p=0.022) were found to be significantly associated with increased risk for lung cancer. Conclusions: Gln/Gln alleles of both XRCC1 and XPD genes appear to amplify the effects of household exposure, smoking and betel quid chewing on lung cancer risk in the study population.