The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

Review of Pharmacological Effects of Coptidis Rhizoma and its Bioactive Compounds

황련(黃連)과 구성 생화합물의 약리작용에 대한 고찰

  • Kim, Ki Bae (Department of Internal Medicine, School of Korean Medicine, Pusan National University) ;
  • Lee, Hyung Tak (Department of Internal Medicine, School of Korean Medicine, Pusan National University) ;
  • Ku, Kyung Howi (Department of Internal Medicine, School of Korean Medicine, Pusan National University) ;
  • Hong, Jin Woo (Department of Internal Medicine, School of Korean Medicine, Pusan National University) ;
  • Cho, Su In (Division of Pharmacology, School of Korean Medicine, Pusan National University)
  • 김기배 (부산대학교 한의학전문대학원 임상의학부 한방내과) ;
  • 이형탁 (부산대학교 한의학전문대학원 임상의학부 한방내과) ;
  • 구경회 (부산대학교 한의학전문대학원 임상의학부 한방내과) ;
  • 홍진우 (부산대학교 한의학전문대학원 임상의학부 한방내과) ;
  • 조수인 (부산대학교 한의학전문대학원 약물의학부)
  • Received : 2012.06.19
  • Accepted : 2012.08.27
  • Published : 2012.09.30
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Abstract

Objectives: Coptidis Rhizoma is one of the most popular and multi-purpose herbs in traditional medicine. The purpose of this study was to contribute to research and applications of Coptidis Rhizoma in clinic, by analyzing and reviewing international studies on its chemical compositions and pharmacological effects. Methods: This study analyzed 344 articles published from 2000 to 2010 in PubMed, Refworks, Riss, and KTKP. The search keywords were "Coptis chinensis", "Coptis japonica", "Coptidis Rhizoma", "huanglian" and "huanglian in Chinese". From them, we selected 114 articles which met our inclusion criteria. Results: This study reviewed 114 articles on Coptidis Rhizoma and its active components in terms of 'Active components', 'Experimental studies', 'Clinical studies', 'Industrial use' and 'Side Effects/Toxicity'. Conclusions: The active components of Coptidis Rhizoma are berberine, coptisine, epiberberine, palmatine, jateorrhizine, magnoflorine, worenine, etc. It is reported that Coptidis Rhizoma and its active components have anti-inflammatory, antibacterial, antitumor, and antioxidant activity, and cardiovascular, hepatoprotective, antidiabetic, neuroprotective, gastrointestinal, pain relieving, discharge phlegm and metrocyte proliferation effects. Moreover, we found that Coptidis Rhizoma can be used for bath preparation, cosmetic products and as a natural antimicrobial substance.

Keywords

References

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