Investigative Magnetic Resonance Imaging

Korean Society of Magnetic Resonance in Medicine (대한자기공명의과학회)
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Acute Adverse Reactions to Gadolinium-based Intravenous Contrast Agents for MRI : Retrospective Analysis Using Computed Reporting System

자기공명영상검사용 가돌리늄 경정맥 조영제의 급성 부작용: 부작용 전산 체계를 이용한 후향적 분석

  • Choi, Moon-Hyung (Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea) ;
  • Choi, Joon-Il (Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea) ;
  • Jung, Seung-Eun (Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea) ;
  • Ahn, Kook-Jin (Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea) ;
  • Lee, Hae-Giu (Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea)
  • 최문형 (가톨릭대학교 서울성모병원 영상의학과) ;
  • 최준일 (가톨릭대학교 서울성모병원 영상의학과) ;
  • 정승은 (가톨릭대학교 서울성모병원 영상의학과) ;
  • 안국진 (가톨릭대학교 서울성모병원 영상의학과) ;
  • 이해규 (가톨릭대학교 서울성모병원 영상의학과)
  • Received : 2011.07.05
  • Accepted : 2011.08.05
  • Published : 2011.08.31
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Abstract

Purpose : To assess the frequency and severity of acute adverse reactions to intravenous administration of gadolinium-based contrast agents using computerized reporting system at a single large academic institution. Materials and Methods : We assessed data from electronic hospital information system from October 2008 to December 2010. Reactions were classified as mild, moderate, or severe. We compared the frequency of adverse reactions among three contrast agents (Gd-BT-DO3A, Gd-DTPA and Gd-EOB-DTPA). Results : The total number of administrated contrast agents was 33,600, and the number of administration of Gd-BT-DO3A, Gd-DTPA and Gd-EOB-DTPA were 20,824 (62%), 10,417 (31%) and 2,359 (7%), respectively. Total 39 adverse reactions were reported accounting for 0.1161% of all administrations. The incidences of adverse reactions were 0.1248% (26/39, 67%) for Gd-BT-DO3A, 0.0768% (8/39, 21%) for Gd-DTPA, and 0.2120% (5/39, 13%) for Gd-EOB-DTPA. The difference of frequencies of adverse reaction among three contrast agents was not significant. Most cases of the adverse effect were mild (35/39, 89.7%). Moderate and severe adverse reactions were encountered in two patients, respectively. Conclusion : Among Koreans, adverse effects were rare, and especially, moderate to severe adverse reactions were much rarer. There was no difference among the frequencies of adverse reactions caused by three different contrast agents.

목적 : 단일기관에서 발생한 가돌리니움 기반의 자기공명영상 경정맥 조영제의 급성 부작용의 빈도 및 종류, 조영제 별 차이를 알아보았다. 대상 및 방법 : 병원정보시스템의 부작용 보고체계를 분석하여, 2008년 10월부터 2010년 12월 사이에 증례를 검색하였다. 부작용은 경증, 중등도, 중증으로 분류되었고 서로 다른 조영제간에 빈도의 차이가 있는지를 분석하였다. 결과 : 총 33,600건의 조영제가 투여되었고, Gd-BT-DO3A 20,824건 (62%), Gd-DTPA 10,417건 (31%), Gd-EOB-DTPA 2,359건 (7%)이었다. 부작용은 총 39예가 발생하여 빈도는 0.1161%였고, Gd-BT-DO3A 0.1248% (26/39,67%), Gd-DTPA 0.0768% (8/39, 21%), Gd-EOB-DTPA 0.2120% (5/39,13%) 였으며, 조영제 간에 유의한 차이는 없었다. 대부분 (89.7%) 이 경증 부작용이었으며 중등도 및 중증 부작용은 각각 2명에서 발생하였다. 결론 : 한국인에서의 자기공명영상 검사용 경정맥 조영제에 의한 부작용의 빈도는 드물었으며, 특히 중등도 혹은 중증 부작용은 매우 드물었다. 세가지 조영제 사이에 부작용 발생 빈도는 차이는 없었다.

Keywords

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