YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Establishment of Library for the Identification of Corticosteroids in Various Known Sample Types

미지시료에서 부신피질호르몬제의 확인을 위한 라이브러리 구축

  • Park, Mee-Jung (Eastern District office, National Forensic Service) ;
  • Hong, Hyo-Jeong (Division of Drug and Toxicology Section, National Forensic Service) ;
  • Lee, Sang-Ki (Division of Drug and Toxicology Section, National Forensic Service)
  • 박미정 (국립과학수사연구원 동부분원 이화학과) ;
  • 홍효정 (국립과학수사연구원 약독물과) ;
  • 이상기 (국립과학수사연구원 약독물과)
  • Received : 2011.07.05
  • Accepted : 2011.08.09
  • Published : 2011.08.31
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Abstract

Illegal addition of steroids into cosmetics, ointments or drugs have been increased and their careless usage induced detrimental effect on health. We developed simultaneous analytical method using TLC, HPLC and LC/MS for the identification of 40 corticosteroids. 34 corticosteroids were well separated in HPLC with isocratic mode and remaining 6 drugs were also separated with gradient mode. All of the 40 corticosteroids were detected in negative mode in LC/MS. Halcinonide, prednisolone, triamcinolone acetonide and methylprednisolone hemisuccinate were detected in real samples.

Keywords

References

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