Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of Triazoloquinoxalines as Antitubercular Agents

  • Received : 2011.02.21
  • Accepted : 2011.06.27
  • Published : 2011.08.20
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Abstract

1,2,4-Triazoles and quinoxalines were found to display various pharmacological activities. Hence a series of 1-aryl-4-methyl-1,2,4-triazolo[4,3-a]quinoxalines were synthesized. Due to various advantages of organic reactions under solvent-free conditions these compounds were developed using iodobenzene diacetate under solvent-free conditions. The synthesized compounds were characterized by elemental microanalysis, infrared spectroscopy, $^1H$ NMR, $^{13}C$ NMR and HRMS. All the synthesized compounds were investigated for their antitubercular activity and 5g was found to the most active compound.

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