대한소아치과학회지 (Journal of the korean academy of Pediatric Dentistry)

  • 제38권2호
  • /
  • Pages.146-154
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  • 2011
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  • 1226-8496(pISSN)
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  • 2288-3819(eISSN)
대한소아치과학회 (Korean Academy of Pediatric Dentistry)
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어린이용 시럽제의 우식유발능에 대한 생체 외 연구

IN VITRO STUDY ON CARIOGENIC POTENTIAL OF SYRUP-FORM MEDICINES FOR CHILDREN

  • 임화신 (원광대학교 치과대학 소아치과학교실) ;
  • 이광희 (원광대학교 치과대학 소아치과학교실) ;
  • 라지영 (원광대학교 치과대학 소아치과학교실) ;
  • 안소연 (원광대학교 치과대학 소아치과학교실) ;
  • 김윤희 (원광대학교 치과대학 소아치과학교실)
  • Lim, Hwa-Shin (Department of Pediatric Dentistry, College of Dentistry, Wonkwang University) ;
  • Lee, Kwang-Hee (Department of Pediatric Dentistry, College of Dentistry, Wonkwang University) ;
  • La, Ji-Young (Department of Pediatric Dentistry, College of Dentistry, Wonkwang University) ;
  • An, So-Youn (Department of Pediatric Dentistry, College of Dentistry, Wonkwang University) ;
  • Kim, Yun-Hee (Department of Pediatonric Dentistry, College of Dentistry, Wonkwang University)
  • 투고 : 2011.02.09
  • 심사 : 2011.03.22
  • 발행 : 2011.05.31
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초록

어린이용 시럽제의 우식유발능에 관해 알아보기 위하여 국내에서 시판 중인 일반의약품 어린이용 시럽제 8종에 대한 생체 외 연구를 사행하였다. 어린이용 시럽제 8종을 실험군으로 10% 자당을 양성 대조군, 인공 타액을 음성 대조군으로 하였다. 실험군 및 대조군의 pH를 측정하고 시료용액 20 ml의 pH를 7로 맞추는데 필요한 2 N NaOH의 부피로 완충능을 측정하였다. Ostwald 파이햇을 시료용액 2 ml가 통과하는데 걸린 시간을 측정하여 비점조도를 계산하였다. Streptococcus mutans의 배양액을 접종 후 48시간 배양하여 pH의 변화를 측정해서 산생성능을 살펴보았다. 하루에 3번 시료용액에 유치 법랑질 시편을 20분간 넣은 후 인공타액에 보관하는 pH 순환모텔을 5일간 적용하였고 표면미세정도의 변화를 측정하여 유치 법랑질 침식능을 검사하였다. 본 연구 결과로부터 어린이용 시럽제는 자체 산도 및 완충능, 점조도, 유치 법랑질 침식능에서 모두 우식유발 가능성이 높음을 알 수 있으며 산생성능에서도 3종를 제외한 어린이용 시럽제가 양성대조군보다 높게 나타남으로써 우식 유발가능성이 높음을보여준다.

An in vitro study on cariogenic potential of 8 over-the-counter syrups for children was performed. The experimental groups were 8 over-the-counter syrups. The positive control group was 10% sucrose solution, and the negative control group was artificial saliva. The pH of each group was determined. The buffering capacity was measured by the volume of 2 N NaOH adding to equalize the pH of 20 ml of experimental solution to pH 7. The consistency was measured by the time to pass Ostwald pipette for 2 ml of the experimental solution. The experimental solutions were inoculated with S. mutans and cultured in $37^{\circ}C$ anaerobic condition for 48 hours. To estimate acid production, pH of the experimental solutions were measured before and after the culture. The primary teeth specimens were soaked in the experimental solutions for 20 minutes three times a day. Except on those hours the specimens were stored in artificial saliva. After 5 days, the microhardness changes of the specimens were measured. These results show that most of syrup-form medicines for children tend to have cariogenic potential partially in endogenous pH, buffering capacity, consistency, acid production and erosive ability of enamel. For the oral health of children, the alternative sweeteners (ex. xylitol) may be substituted for the cariogenic sweeteners of syrups. Additionally, It may be helpful that the chewable tablet replace liquid or syrup in term of dose form.

키워드

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피인용 문헌

  1. Cariogenic Potential of Nutritional Supplements for Children on Bovine Teeth vol.41, pp.3, 2014, https://doi.org/10.5933/JKAPD.2014.41.3.233