YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Structure Activity Relationship of Methylchroman-2-carboxylic Acid N-(Disubstituted)phenylamide Derivatives as Potential NF-${\kappa}B$ Inhibitors

메틸크로만-2-카르복실산 N-(이치환)페닐아마이드 유도체의 NF-${\kappa}B$ 저해 구조-활성 상관 관계

  • Received : 2011.03.09
  • Accepted : 2011.03.21
  • Published : 2011.04.30
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Abstract

During the search for a novel compound that can inhibit NF-${\kappa}B$ activation, 6-hydroxy-7-methoxychroman-2-carboxylic acid phenyl amide (KL-1156) was identified as a good inhibitor of NF-${\kappa}B$ activation. In the present study, we describe the synthesis of methylchroman-2-carboxylic acid N-(disubstituted)phenylamide derivatives (1 and 2 serieses). In addition, their inhibitory effects of NF-${\kappa}B$ are compared with activity of KL-1156 and SAR (structure activity relationship) are explored.

Keywords

References

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