Tuberculosis and Respiratory Diseases

  • 제70권3호
  • /
  • Pages.218-223
  • /
  • 2011
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  • 1738-3536(pISSN)
  • /
  • 2005-6184(eISSN)
대한결핵및호흡기학회 (The Korean Academy of Tuberculosis and Respiratory Diseases)
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Effects of Curcumin and Genistein on Phorbol Ester or Tumor Necrosis Factor-${\alpha}$-Induced Mucin Production from Human Airway Epithelial Cells

  • Lee, Su-Yel (Department of Pharmacology, Chungnam National University College of Medicine) ;
  • Lee, Hyun-Jae (Department of Pharmacology, Chungnam National University College of Medicine) ;
  • Lee, Jae-Woo (LG Life Science) ;
  • Jeon, Byeong-Kyou (Department of Radiologic Technology, Daegu Health College) ;
  • Kim, Ju-Ock (Pulmonology Section, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University College of Medicine) ;
  • Lee, Choong-Jae (Department of Pharmacology, Chungnam National University College of Medicine)
  • 투고 : 2010.10.12
  • 심사 : 2010.12.08
  • 발행 : 2011.03.30
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초록

Background: We investigated whether curcumin and genistein affect the MUC5AC mucin production from human airway epithelial cells that is induced by phorbol 12-myristate 13-acetate (PMA) or tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$). Methods: Confluent NCI-H292 cells were pretreated with each agent for 30 min and then stimulated with PMA or TNF-${\alpha}$ for 24 hours. MUC5AC mucin production was measured by an ELISA. Results: (1) Curcumin dose-dependently inhibited the production of MUC5AC mucin that was induced by PMA or TNF-${\alpha}$; (2) Genistein inhibited PMA-induced MUC5AC mucin production. However, it did not decrease TNF-${\alpha}$-induced MUC5AC mucin production. Conclusion: These results suggest that curcumin and genistein inhibit the production of airway mucin induced by PMA.

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참고문헌

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