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The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Acute Toxicity Assessment of New Algicide, Thiazolidinedione Derivative (TD53) to Marine Ecosystem

신규 살조물질인 Thiazolidinedione 유도체 (TD53)의 해양생태계에 대한 급성독성평가

  • Yim, Eun-Chae (Collaborate course of Bioenergy and Biomaterial, Chonnam National University) ;
  • Shin, Jun-Jae (Collaborate course of Bioenergy and Biomaterial, Chonnam National University) ;
  • Park, In-Taek (Dept. of Civil, Earth and Environmental Engineering, college of Engineering, Chonnam National University) ;
  • Han, Hyo-Kyung (College of Pharmacy, Dongguk University) ;
  • Kim, Si-Wouk (Department of Environmental Engineering, Chosun University) ;
  • Cho, Hoon (Department of polymer science & Chemical Engineering, Chosun University) ;
  • Kim, Seong-Jun (Dept. of Civil, Earth and Environmental Engineering, college of Engineering, Chonnam National University)
  • 임은채 (전남대학교 바이오에너지 및 바이오소재협동과정) ;
  • 신준재 (전남대학교 바이오에너지 및 바이오소재협동과정) ;
  • 박인택 (전남대학교 환경공학과) ;
  • 한효경 (동국대학교 약학대학 약학과) ;
  • 김시욱 (조선대학교 환경공학과) ;
  • 조훈 (조선대학교 응용화학소재공학과) ;
  • 김성준 (전남대학교 환경공학과)
  • Received : 2010.12.13
  • Accepted : 2011.01.11
  • Published : 2011.02.28
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Abstract

In order to perform an acute toxicity assessment of a new algicide, thiazolidinedione derivative (TD53) with enhanced solubility and lower toxicity to marine ecosystem, representative 3 organisms: plant plankton (Skeletonema costatum), animal plankton (Daphnia magna), fish (Paralichthys olivaceus) related in the food chain of marine ecosystem according to OECD standard methods were employed in the exposure experiment. The exposure assessment showed that $EC_50$ of S. costatum in 96-hour, $EC_50$ of D. magna in 48-hour and $LC_50$ of P. olivaceus in 72-hour for TD53 were $1.53\;{\mu}M$, $0.61\;{\mu}M$ and $2.14\;{\mu}M$ respectively. NOEC (No Observed Effect Concentration) and PNEC (Predicted No Effect Concentration) were calculated to be $0.25\;{\mu}M$ and 6.10 nM, respectively from $EC_50$ of most sensitive strain, D. magna. Comparing with the results of toxicity assessment previously performed by using Ulva pertusa Kjellman accepted as an ISO standard method, the values of PNEC showed 3.7 times lower toxicity in case of this study employing 3 organisms, indicating that if the organisms which are more representative and sensitive in marine ecosystem are further investigated, more accurately and validly predicted toxicity of TD53 could be applied in field.

Keywords

References

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