Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Chemical Modification of Rupestonic Acid and Preliminarily In Vitro Antiviral Activity Against Influenza A3 and B Viruses

  • Yong, Jian-Ping (School of Public Health in Ningxia Medical University) ;
  • Aisa, Haji Akber (Xinjiang Technical Institute of Physics and Chemistry, The Key Laboratory of Plant Resources and Natural Products Chemistry, Chinese Academy of Sciences)
  • Received : 2011.01.05
  • Accepted : 2011.02.21
  • Published : 2011.04.20
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Abstract

To improve the biological activities of rupestonic acid, 21 new rupestonic acid fatty ester derivatives (2a-2h) and aromatic ester derivatives (2i-2u) were synthesized and preliminarily evaluated for their anti-influenza activity in vitro by the national center for drug screening of China, using the Oseltamivir and Ribavirin as reference drugs. The results showed that 2l ($IC_{50}=0.5{\mu}mol/L$) exhibited potent anti-influenza $A_3$ viral activity among the synthesized compounds and was 10-fold more potent than that of the reference drug Oseltamivir ($IC_{50}=5.1{\mu}mol/L$).

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References

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