Journal of fish pathology (한국어병학회지)

The Korean Society of Fish Pathology (한국어병학회)
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Papillomatosis on the skin of the wild marbled sole Pleuronectes yokohamae

자연산 문치가자미, Pleuronectes yokohamae 피부의 육아종

  • Park, Jung-Jun (Pathology Division, National Fisheries Research and Development Institute) ;
  • Byoun, Ju-Young (Safety and Environment Department, Korea Hydro and Nuclear Power Co., Ltd.) ;
  • Choi, Hye-Sung (Pathology Division, National Fisheries Research and Development Institute) ;
  • Park, Myoung-Ae (Pathology Division, National Fisheries Research and Development Institute) ;
  • Kwon, Mun-Gyeong (Pathology Division, National Fisheries Research and Development Institute) ;
  • Kim, Seok-Ryel (Pathology Division, National Fisheries Research and Development Institute)
  • 박정준 (국립수산과학원 병리연구과) ;
  • 변주영 ((주)한국수력원자력) ;
  • 최혜승 (국립수산과학원 병리연구과) ;
  • 박명애 (국립수산과학원 병리연구과) ;
  • 권문경 (국립수산과학원 병리연구과) ;
  • 김석렬 (국립수산과학원 병리연구과)
  • Received : 2011.08.04
  • Accepted : 2011.09.14
  • Published : 2011.12.31
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Abstract

Among wild marbled sole, Pleuronectes yokohamae caught in west coastal area, Chungnam, tumor-bearing fish were found. Parasites and pathogenic bacteria were not detected and CPE was not observed. Using the light microscope, the epidermal layer of wild P. yokohamae was significantly thickened compared to the normal skin. The lesion was formed papillary folds. Hypertropical epithelial cells revealed karyolysis, marked nucleolus and cloud swelled cytoplasm. In the epidermal layer of the lesion, X-cell that is characterized by oval and small pale nucleus and prominent nucleolus was observed. Dermal layer had newly formed vessels. The size of mucous cell in the papilloma lesion was significantly increased compared to the normal. In this study, no pathogens were found, so future works for finding cause of the papilloma in the P. yokohamae are needed.

충청남도 보령시 인근연안에서 어획된 문치가자미, Pleuronectes yokohamae 10개체 중에서 6개체가 피부에 육아종이 형성되었다. 기생충과 병원균으로 의심되는 세균은 증식하지 않았으며, 환부의 균질액을 CHSE-214 세포에 접종하였으나 CPE가 관찰되지 않았다. 환부를 광학현미경으로 관찰하였을 때 상피 세포의 증식으로 상피층은 정상개체와 비교하였을 때 유의적인 차이를 보이며 두꺼워졌고, 육아종 주름이 형성되었다. 비대되어진 상피세포는 핵융해 및 뚜렷하게 관찰되는 인이 특징이었으며, 세포질은 혼탁하였다. 이들 상피층에는 원형의 작은 핵과, 뚜렷한 인이 관찰되는 X-cell이 존재하였다. 진피층에는 다수의 신생 혈관들이 존재하고 있었다. 점액세포의 크기는 정상개체와 비교하였을때 유의적인 차이를 보이며 증가하였다. 본 연구에서는 병원체가 확인되지 않았지만 추가적인 실험을 통해서 원인체를 확인해야 할 것으로 생각된다.

Keywords

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