Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Cytotoxic Sesquiterpenoid from the Seeds of Amomum xanthioides

  • Kim, Ki-Hyun (Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University) ;
  • Choi, Jung-Wook (Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University) ;
  • Choi, Sang-Un (Korea Research Institute of Chemical Technology) ;
  • Lee, Kang-Ro (Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University)
  • Received : 2011.02.01
  • Accepted : 2011.03.15
  • Published : 2011.03.31
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Abstract

As parts of our continuing search for biologically active compounds from medicinal plants, we investigated the constituents of the seeds of Amomum xanthioides and isolated a sesquiterpenoid, a nerolidol derivative from its MeOH extract. The chemical structure was determined by spectroscopic methods, including 1D and 2D NMR to be ($2S^*$,$2'R^*$,$5'S^*$)-2-(5'-ethenyltetrahydro-5'-methylfuran-2'-yl)-6-methylhept-5en-2-ol (1). Compound 1 was isolated for the first time from nature source. Compound 1 exhibited a good cytotoxicity against SK-OV-3 and SK-MEL-2 cells ($IC_{50}$: 16.7 and $8.6\;{\mu}M$, respectively) using a SRB bioassay. In this study, we also determined the absolute configuration of 2 reported in previous paper.

Keywords

References

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