한국식품위생안전성학회지 (Journal of Food Hygiene and Safety)

  • 제26권4호
  • /
  • Pages.377-382
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  • 2011
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  • 1229-1153(pISSN)
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  • 2465-9223(eISSN)
한국식품위생안전성학회 (The Korean Society of Food Hygiene and Safety)
권호 표지

염화벤지코늄과 구연산을 주성분으로 하는 살균 소독제 라미아-킬에 대한 급성경구독성 및 피부자극성 시험에 관한 연구

Acute Oral Toxicity and Skin Irritation Studies on Lamia-Kill$^{(R)}$ Composed of Benzalkonium Chloride and Citric Acid

  • 차춘남 (경상대학교 산업시스템공학부 공학연구원) ;
  • 이여은 (경상대학교 보건대학원 환경보건학과) ;
  • 손송이 (경상대학교 수의과대학 생명과학연구원) ;
  • 유창열 (경남도립남해대학 인터넷정보학과) ;
  • 박은기 (고신대학교 의과대학) ;
  • 최현주 (인제대학교 임상병리학과, 고령자라이프디자인연구소) ;
  • 김석 (경상대학교 수의과대학 생명과학연구원) ;
  • 이후장 (경상대학교 수의과대학 생명과학연구원)
  • Cha, Chun-Nam (Engineering Research Institute, Department of Industrial Systems Engineering, Gyeongsang National University) ;
  • Lee, Yeo-Eun (Department of Environmental Health, Graduate School of Public Health, Gyeongsang National University) ;
  • Son, Song-Ee (Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University) ;
  • Yoo, Chang-Yeol (Department of Computer Information, Gyeongnam Provincial Namhae College) ;
  • Park, Eun-Kee (Department of Medical Humanities and Social Medicine, College of Medicine, Kosin University) ;
  • Choi, Hyun-Ju (Elderly Life Redesign Institute, Department of Biomedical Laboratory Science, Inje University) ;
  • Kim, Suk (Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University) ;
  • Lee, Hu-Jang (Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University)
  • 투고 : 2011.11.01
  • 심사 : 2011.11.15
  • 발행 : 2011.12.31
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초록

살균소독제, 라미아-킬(benzalkonium chloride(20%), citric acid(20%))에 대하여 랫드와 토끼를 이용하여 급성경구독 성과 피부 자극성 평가를 각각 수행하였다. 랫드에 라미아-킬 2,000 mg/kg 농도를 최고농도로 하여 단회 투여 후, 14일간 관찰한 결과, 사망, 이상증상 및 체 중변화 등은 관찰되지 않아, 라미아-킬의 $LD_{50}$은 2,000 mg/kg 이상으로 추정되었다. 토끼의 등 부위의 털을 제거하고 찰과부위와 비찰과 부위에 여러 농도로 라미아-킬을 도포 한 후, 피부 자극성을 확인한 결과, 라미아-킬의 l차 자극 지수가 0.50으로 비자극성 물질로 분류되었다. 따라서, 본 연구를 통하여, 라미아-킬은 급성경구독성 시 안전한 물질이며, 피부 자극성을 야기하지 않는 물질로 평가되었다.

This test was performed to evaluate the acute oral toxicity and skin irritation of Lamia-Kill$^{(R)}$, disinfectant, containing 20% benzalkonium chloride and 10% citric acid. In acute oral toxicity, Lamia-Kill$^{(R)}$ was orally administered at dose levels of 2,000, 1,000, 500, 250 and 0 mg/kg body weight. After single oral administration to both sexes of SD rats, the rats were observed for 14 days. In primary skin irritation test, New Zealand white rabbits were dermally treated with Lamia-Kill$^{(R)}$ for 24 hr and observed for 3 days. All rats treated with Lamia-Kill$^{(R)}$ were induced no toxic signs in mortalities, clinical findings, body weights and gross findings. Also, the disinfectant did not induce any adverse reactions such as erythema and edema on intact skin sites for the most part rabbits, but on abraded skin sites, some rabbits showed very slight erythema on 24 hr after topical application. With the results of this study, Lamia-Kill$^{(R)}$ have no effect on acute toxicity and side effect in SD rats and was classified as a practically non-irritating material based on the score 0.50 of primary irritation index.

키워드

참고문헌

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