Safety and Health at Work

  • 제2권1호
  • /
  • Pages.65-69
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  • 2011
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  • 2093-7911(pISSN)
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  • 2093-7997(eISSN)
산업안전보건연구원 (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency)
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Multi-Walled Carbon Nanotube (MWCNT) Dispersion and Aerosolization with Hot Water Atomization without Addition of Any Surfactant

  • Ahn, Kang-Ho (Department of Mechanical Engineering, Hanyang University) ;
  • Kim, Sun-Man (Department of Mechanical Engineering, Hanyang University) ;
  • Yu, Il-Je (Toxicological Research Center, Hoseo University)
  • 투고 : 2010.09.14
  • 심사 : 2011.01.04
  • 발행 : 2011.03.30
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초록

Objectives: Carbon nanotubes are an important new class of technological materials that have numerous novel and useful properties. Multi-walled carbon nanotubes (MWCNTs), which is a nanomaterial, is now in mass production because of its excellent mechanical and electrical properties. Although MWCNTs appear to have great industrial and medical potential, there is little information regarding their toxicological effects on researchers and workers who could be exposed to them by inhalation during the handling of MWCNTs. Methods: The generation of an untangled MWCNT aerosol with a consistent concentration without using surfactants that was designed to be tested in in vivo inhalation toxicity testing was attempted. To do this, MWCNTs were dispersed in deionized water without the addition of any surfactant. To facilitate the dispersion of MWCNTs in deionized water, the water was heated to $40^{\circ}C$, $60^{\circ}C$, and $80^{\circ}C$ depending on the sample with ultrasonic sonication. Then the dispersed MWCNTs were atomized to generate the MWCNT aerosol. After aerosolization of the MWCNTs, the shapes of the NTs were examined by transmission electron microscopy. Results: The aerosolized MWCNTs exhibited an untangled shape and the MWCNT generation rate was about 50 $mg/m^3$. Conclusion: Our method provided sufficient concentration and dispersion of MWNCTs to be used for inhalation toxicity testing.

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참고문헌

  1. Dobrovolskaia MA, McNeil SE. Immunological properties of engineered nanomaterials. Nat Nanotechnol 2007;2:469-78. https://doi.org/10.1038/nnano.2007.223
  2. Chakravarty P, Marches R, Zimmerman NS, Swafford AD, Bajaj P, Musselman IH, Pantano P, Draper RK, Vitetta ES. Thermal ablation of tumor cells with antibody-functionalized single-walled carbon nanotubes. Proc Natl Acad Sci U S A 2008;105:8697-702. https://doi.org/10.1073/pnas.0803557105
  3. Maynard AD, Baron PA, Foley M, Shvedova AA, Kisin ER, Castranova V. Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material. J Toxicol Environ Health A 2004;67:87-107. https://doi.org/10.1080/15287390490253688
  4. Shvedova AA, Castranova V, Kisin ER, Schwegler-Berry D, Murray AR, Gandelsman VZ, Maynard A, Baron P. Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J Toxicol Environ Health A 2003;66:1909-26. https://doi.org/10.1080/713853956
  5. Tabet L, Bussy C, Amara N, Setyan A, Grodet A, Rossi MJ, Pairon JC, Boczkowski J, Lanone S. Adverse effects of industrial multiwalled carbon nanotubes on human pulmonary cells. J Toxicol Environ Health A 2009;72:60-73. https://doi.org/10.1080/15287390802476991
  6. Myojo T, Oyabu T, Nishi K, Kadoya C, Tanaka I, Ono- Ogasawara M, Sakae H, Shirai T. Aerosol generation and measurement of multi-wall carbon nanotubes. J Nanopart Res 2009;11:91-9. https://doi.org/10.1007/s11051-008-9450-8
  7. Baron PA, Maynard AD, Foley M. Evaluation of aerosol release during the handling of unrefined single walled carbon nanotube material. NIOSH 2003; DART-02-191 Rev. 1.1.
  8. Fujitani Y, Furuyama A, Hirano S. Generation of airborne multi-walled carbon nanotubes for inhalation studies. Aerosol Science Technology 2009;43:881-90. https://doi.org/10.1080/02786820903002423
  9. Lide DR. CRC handbook of chemistry and physics. 77th ed. New York: CRC Press; 1997. p. 6-3.
  10. Tittarelli A, Borgini A, Bertoldi M, De Saeger E, Ruprecht A, Stefanoni R, Tagliabue G, Contiero P, Crosignani P. Estimation of particle mass concentration in ambient air using a particle counter. Atmospheric Environ 2008;42:8543-8. https://doi.org/10.1016/j.atmosenv.2008.07.056
  11. Han JH, Lee EJ, Lee JH, So KP, Lee YH, Bae GN, Lee SB, Ji JH, Cho MH, Yu IJ. Monitoring multiwalled carbon nanotube exposure in carbon nanotube research facility. Inhal Toxicol 2008;20:741-9. https://doi.org/10.1080/08958370801942238
  12. Ku BK, Maynard AD, Baron PA, Deye GJ. Observation and measurement of anomalous responses in a differential mobility analyzer caused by ultrafine fibrous carbon aerosols. J Electrostatics 2007;65:542-8. https://doi.org/10.1016/j.elstat.2006.10.012
  13. Lee JH, Lee SB, Bae GN, Jeon KS, Yoon JU, Ji JH, Sung JH, Lee BG, Lee JH, Yang JS, Kim HY, Kang CS, Yu IJ. Exposure assessment of carbon nanotube manufacturing workplaces. Inhal Toxicol 2010;22:369-81. https://doi.org/10.3109/08958370903367359
  14. Poland CA, Duffin R, Kinloch I, Maynard A, Wallace WA, Seaton A, Stone V, Brown S, Macnee W, Donaldson K. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol 2008;3:423-8. https://doi.org/10.1038/nnano.2008.111
  15. Takagi A, Hirose A, Nishimura T, Fukumori N, Ogata A, Ohashi N, Kitajima S, Kanno J. Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube. J Toxicol Sci 2008;33:105-16. https://doi.org/10.2131/jts.33.105
  16. Muller J, Delos M, Panin N, Rabolli V, Huaux F, Lison D. Absence of carcinogenic response to multiwall carbon nanotubes in a 2-year bioassay in the peritoneal cavity of the rat. Toxicol Sci 2009;110:442-8. https://doi.org/10.1093/toxsci/kfp100
  17. Mitchell LA, Gao J, Wal RV, Gigliotti A, Burchiel SW, Mc- Donald JD. Pulmonary and systemic immune response to inhaled multiwalled carbon nanotubes. Toxicol Sci 2007;100: 203-14. https://doi.org/10.1093/toxsci/kfm196
  18. McKinney W, Chen B, Frazer D. Computer controlled multiwalled carbon nanotube inhalation exposure system. Inhal Toxicol 2009;21:1053-61. https://doi.org/10.1080/08958370802712713

피인용 문헌

  1. Genotoxicity of Silver Nanoparticles in Lung Cells of Sprague Dawley Rats after 12 Weeks of Inhalation Exposure vol.1, pp.1, 2013, https://doi.org/10.3390/toxics1010036
  2. genotoxicity evaluation of lung cells from Fischer 344 rats following 28 days of inhalation exposure to MWCNTs, plus 28 days and 90 days post-exposure vol.26, pp.4, 2014, https://doi.org/10.3109/08958378.2013.878006
  3. Inhalation Exposure to Carbon Nanotubes (CNT) and Carbon Nanofibers (CNF): Methodology and Dosimetry vol.18, pp.3-4, 2015, https://doi.org/10.1080/10937404.2015.1051611
  4. Continuous dry dispersion of multi-walled carbon nanotubes to aerosols with high concentrations of individual fibers vol.20, pp.6, 2018, https://doi.org/10.1007/s11051-018-4262-y