The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Experimental Studies on the Antidiarrheal Effects of Anjang-san

  • Oh, Seung-Whan (Kyung Hee University Graduate School of Oriental Medicine) ;
  • Ryu, Bong-Ha (3rd Department of Internal Medicine, Kyung Hee University Oriental Medicine Hospital)
  • Received : 2011.10.19
  • Accepted : 2011.11.09
  • Published : 2011.11.30
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Abstract

Objectives: The purpose of the present study was to investigate the antidiarrheal effects of Anjang-san in mice and rats. Methods: We measured the content of condensed tannin in Anjang-san extract, and observed the effects of Anjang-san on the small intestinal and colonic transport of mice, as well as on mice models of diarrhea induced by castor oil and $MgSO_4$, and on rat models of castor oil-induced enteropooling. Results: Anjang-san showed significant inhibitory effects on abnormally increased small intestinal transit induced by pyridostigmine and neostigmine, and inhibitory effects on large intestinal transit. Anjang-san also exhibited antidiarrheal effects on diarrhea induced by $MgSO_4$, and inhibitory effects on castor oil-induced enteropooling. Anjang-san also improved castor oil-induced diarrhea based on simple numbers without statistical significance. Conclusion: These results demonstrate that Anjang-san has significant antidiarrheal properties and attests to its possible utility in functional diarrheas, irritable bowel syndrome and other gastrointestinal disorders based upon further studies.

Keywords

References

  1. Kim JR. Gastrointestinal diseases. Seoul: Iljogak. 2000:52-62
  2. Korean association of college of oriental medicine, Department of internal medicine (spleen system). Internal medicine (spleen system). Seoul: Koonja.2008:177-88
  3. Ryu BH, Jang IK. Experimental studies on the effects of Yukgunja-tang. Bulletin of Kyung Hee University. 1984; 7:53-71
  4. Ryu IS, Ryu BH, Kim JS. Experimental Studies on the Anti-diarrhea Effects of Jisa-tang. Korean J. Orient. Int. Med. 2008; 29(2):348-58
  5. No WS, Ryu BH, Kim JS, Yoon SH. Experimental Studies on the Anti-cathartic Effects of Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tang. Korean J. Orient. Int. Med. 2006; 27(2):356-70
  6. Broadhurst R, Jones W. Analysis of condensed tannins using acidified vanillin. J. Sci. Fd. Agric. 1978; 29:788-794 https://doi.org/10.1002/jsfa.2740290908
  7. Ishi Y, Tanizawa H, Ikemoto C, Takino Y. Studies of Aloe. I. Cathartic Effects. Yakugaku Zasshi. 1981; 101(3):254-258
  8. Ishi Y, Tanizawa H, Takino Y. Studies of Aloe. II. Mechanism of Cathritic Effect. Yakugaku Zasshi. 1988; 108(9):904-910
  9. Saitoh K, Kase Y, Ishige A, Komatsu A, Sasaki H, Shibata N. Effects of Keishi-ka-shakuyaku-to (Gui-Zhi-Jia-Yao-Tang) on diarrhea and small intestinal movement. Bio. Pharm. Bull. 1999; 22:87-89 https://doi.org/10.1248/bpb.22.87
  10. Sagar L, Sehgal R, Ojha S. Evaluation of antimotility effect of Lantana camara L. var. acuelata constituents on neostigmine induced gastrointestinal transit in mice. BMC Com. Alter. Med. 2005; 5(18):1-6
  11. Miyawaki Y, Chin M, Yagi T, Yamaguchi K, Kuwano S. Purgative activity of Daio-kanzo-to (Da-Huang-Gan-Cao-Tang) in rats-potentiating effect of glycyrrhiza on the purgative action of rhubarb. J. Med. and Pharm. Soci. for WAKAYAKU. 1993; 10:97
  12. Havagiray RC, Ramesh C, Dadhna K. Studies on anti-diarrheal activity of Calotropis gigantea R.BR in experimental animals. J. Pharmaceut Sci. 2004;7:70-75
  13. Perianayagam JB, Narayanan S, Gnanasekar G, Pandurangan A, Raja S, Rajagopal K, et al. Evaluation of antidiarrheal potential of Emblica officinalis. Pharmaceutical Biology. 2005; 43:373-377 https://doi.org/10.1080/13880200590951856
  14. Choi HJ. Diarrhea -Focusing on the mechanism-. Korean J Gastroenterol. 1973; Spring symposium: 33-37
  15. Song IS. Chronic diarrhea. Korean J Gastroenterol. 2002; 14th seminar:46
  16. Lee SH, Lee BY. Consideration of Literatures on diarrhea's etiological cause and pathological alternation, and the treatment of diarrhea with Acupuncture ＆ Moxibustion therapy. Bulletin of Research Institute of Korean Medicine, Daejon. 1998; 6(2):627-648
  17. Cao X. Sheng Ji Zong Lu. Beijing: People's Medical Publishing House. 1962:1318-1331
  18. Korean association of oriental medical physiology. Oriental medical physiology. Seoul: Kyung Hee University Publishing House. 1993:139-141
  19. Heo J. Donguibogam. Seoul: Namsandang. 1991: 150
  20. Jang TS, Jung HC, Ryu BH. A comparative study on the symptoms and complications between diabetes-mellitus and so-gal. Korean J. Orient. Int. Med. 1985; 2(1):61-69
  21. Han KE, Jang IK. Experimental studies on the efficacy of Pyungjin-tang. J Korean Oriental Med. 1991; 12(1):276-298.
  22. Jeon WH. Effects of Jeongjangbobi-tang on gastrointestinal function and inhibition of gastric cancer cell proliferation. Bulletin of Kyung Hee University. 2000; 23(1):17-34
  23. Song DS. Experimental studies on the efficacy of Samryungbaekchulsan. J Korean Oriental Med. 1993; 14(1):179-195
  24. Ahn JR. Experimental Studies on the Effects of Kamikwakjeongtang. J Korean Oriental Med.1994; 15(2):184-197
  25. Kang JC. An experimental research of the efficacy of Youryungtang. J Korean Oriental Med. 1993; 14(1):157-168
  26. Chun JH. Experimental studies on the effects of Bojanggunbitang. J Korean Oriental Med. 1994; 15(1):83-99
  27. Kong HS. Experimental studies on the efficacy of Siljangsan. Korean J. Orient. Int. Med. 1995; 15(2):197-208
  28. Jung WY. The efficiency of Jungritang on gastrointestinal organs of rats. Bulletin of Kyung Hee University. 1998; 21(1):213-223
  29. Kim YG. A Study on the Effects of Pyungwee-san in the Movement of Gastrointestinal Smooth Muscles, Anticatharsis, and Central Nervous System. Bulletin of Kyung Hee University. 1999; 22(1): 185-202
  30. Lee KM. Anticathartic Effect of Myristicae semen, Granati pericarpium and Alpiniae katsumadai semen. Korean J. Orient. Int. Med. 2006; 27(2):459-470
  31. Society of Pharmaceutical Botany. Experimental Pharmaceutical Botany. Seoul: Korean Learning Material Publishing House. 1980:219
  32. Shin MK. Colored clinical herbology. Seoul: Younglimsa. 1992:337
  33. Ofuji K, Hara H, Sukamoto T, Yamashita S. Effects of an antidiarrhoeica containing an extract from geranium herb on astringent action and short-circuit current across jejunal mucosa. Nihon Yakurigaku Zasshi. 1998; 111(4):265-75. https://doi.org/10.1254/fpj.111.265
  34. Wang LM, Lu CF, Lu YZ, Fu ZZ, Liu Z. Antidiarrhea effect of Herba Geranium tannins. Heilongjiang Medicine and Pharmacy. 2003; 26(5):28-29
  35. Song H. Research progress of pharmacological effects of Geranium wilfordii. Chinese Traditional and Herbal Drugs. 1997; 28:132-133
  36. Na DQ, Wei QD, Zhao H, Na ZY, Li HL. Experimental study of bacteriostasis of Geranium wilfordii soft extract in vivo and in vitro and acute toxicity test. Chinese Journal of Ethnomedicine and Ethnopharmacy. 1998;34: 32-35
  37. Korean association of college of oriental medicine, Herbology. Herbology. Seoul: Younglimsa. 1994: 297, 539, 540, 542, 611, 612
  38. Seo BI, Choi HY. Clinical oriental medical herbology. Seoul: Younglimsa. 2004:389, 785, 787, 792, 915
  39. Li ZX, Wang XH, Yue YS, Zhao BZ, Chen JB, Li JH. Anti-bacterial effect of Terminalia chebula on 355 clinical strains in vitro. Chinese Journal of Traditional Medical Science and Technology. 2000; 7(6):393-394
  40. Sato Y, Oketan Hi, Singyouchi K, Ohtsubo T, Kihara M, Shibata H et al. Extraction and purification of effective antimicrobial constituents of Terminalia chebula Retz. against methicillinresistant Staphylococcus aureus. Biological & Pharmaceutical Bulletin. 1997; 20(4):401-404 https://doi.org/10.1248/bpb.20.401
  41. Grover JK, Khandkar S, Vats V, Dhunnoo Y, Das D. Pharmacological studies on Myristica fragrans-antidiarrheal, hypnotic, analgesic and hemodynamic (blood pressure) parameters. Methods Find Exp Clin Pharmacol. 2002; 24(10):675-80. https://doi.org/10.1358/mf.2002.24.10.802317
  42. Weissinger J. Effect of nutmeg, aspirin, chlorpromazine and lithium on normal intestinal transport. Proceedings of the Western Pharmacology Society. 1985; 28:287-293
  43. Association of oriental pharmacology. Oriental pharmacology. Seoul: Shinil Books. 2006:115, 135, 529, 568, 602, 621, 635
  44. Kim NJ, Hong ND. Quality control of herbal medicine. Seoul: Shinil Books. 2007:370, 408, 417
  45. Association of Pharmacognosy. Contemporary pharmacognosy. Seoul: Hakchangsa. 1992:236
  46. Woo WS. Research method of Chemistry of Natural Products. Seoul: Mineumsa. 1984:117
  47. Hong ND, Kim NJ. Development and usage of medical products from natural products. Yakup Daily. 2009;192
  48. Association of Chemistry of natural products. Chemistry of natural products. Seoul: Younglimsa. 1995:289-291
  49. Okuda T, Ito H. Tannins of constant structure in medicinal and food plants-Hydrolyzable and polyphenols related to tannins. Molecules. 2011; 16;2191-2217 https://doi.org/10.3390/molecules16032191
  50. Han DS. Pharmacology. Seoul: Pharmacist Research. 1976:139
  51. Goodman JL, Gilman A. Goodman and Gilman's The Pharmacological Basis of Therapeutics. New York: McGraw-Hill. 2005:1261
  52. Yamamoto K, Takase H, Abe K, Saito Y, Suzuki A. Pharmacological studies on antidiarrheal effects of a preparation containing Berberine and Geranii Herba. Folia pharmacol. japon. 1993; 101:169- 175 https://doi.org/10.1254/fpj.101.3_169
  53. Stewart JJ, Gaginella TS, Olsen WA, Bass P. Inhibitory actions of laxatives on motility and water and electrolyte transport in the gastrointestinaltract. J. Pharmacol. Exp. Ther. 1975; 192:458-467
  54. Ataka K, Ito M, Shibata T. New views on antidiarrheal effect of wood creosote: Is wood creosote really a gastrointestinal antispetic? Yakugaku Zasshi. 2005; 125:937-950 https://doi.org/10.1248/yakushi.125.937
  55. Ammon HV, Thomas PJ, Phillips S. Effect of oleic and ricinoleic acid on net jejunal water and electrolyte movement. J. Clin. Invest. 1974; 53:374-379 https://doi.org/10.1172/JCI107569
  56. Robert A, Nezamis JE, Lancaser C, Hanchar AJ, Klepper MS. Enteropooling assay; a test for diarrhea produced by prostaglandins. Prostaglandins. 1976; 11(5):809-828 https://doi.org/10.1016/0090-6980(76)90189-1
  57. Mascolo N, Izzo AA, Avtore G, Barboto F, Capasso F. Nitric oxide and castor oil induced diarrhea. J. Pharmacol. Exper. Thera. 1994; 268: 291-293