The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
권호 표지

An Adrenal Cortical Adenoma with Adrenal Medullary Hyperplasia

부신수질증식증이 동반된 알도스테론 분비 부신피질선종 1예

  • Lee, Hyang-Sun (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Kim, Gun-Woo (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Kim, Jae-Hyun (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Lee, Mi-Young (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Eum, Min-Sub (Department of Pathology, Yonsei University Wonju College of Medicine) ;
  • Shin, Young-Goo (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Chung, Choon-Hee (Department of Internal Medicine, Yonsei University Wonju College of Medicine)
  • 이향선 (연세대학교 원주의과대학 내분비내과학교실) ;
  • 김건우 (연세대학교 원주의과대학 내분비내과학교실) ;
  • 김재현 (연세대학교 원주의과대학 내분비내과학교실) ;
  • 이미영 (연세대학교 원주의과대학 내분비내과학교실) ;
  • 엄민섭 (연세대학교 원주의과대학 병리학교실) ;
  • 신영구 (연세대학교 원주의과대학 내분비내과학교실) ;
  • 정춘희 (연세대학교 원주의과대학 내분비내과학교실)
  • Published : 2011.09.01
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Abstract

The relationship between the adrenal cortex and medulla has been studied since the 1960s. Rarely, a patient with an adrenal cortical adenoma presents with the findings of pheochromocytoma. However, there has been no report of a case with the clinical features of pheochromocytoma showing the pathological features of an adrenal cortical adenoma with medullary hyperplasia on histological examination. We report a 59-year-old-man who was shown to have an adrenal cortical adenoma, with medullary hyperplasia, during a diagnostic work up for pheochromocytoma.

부신피질과 수질은 서로 다른 기원과 기능을 가지고 있으나 드물게 혼합된 임상소견을 보이는 경우가 보고되고 있다. 저자 등은 갈색세포종의 증상을 보여 시행한 호르몬 검사상 알도스테론 분비 부신피질선종의 소견을 보인 환자에서 수술 후 병리 조직 소견상 부신피질선종과 부신수질증식증이 동반된 드문 경우가 있어 문헌고찰과 함께 국내에서 처음으로 보고하는 바이다.

Keywords

References

  1. Williams RH, Larsen PR. Wiliams Textbook of Endocrinology. 10th ed. Philadelphia: Saunders, 2003.
  2. Alsabeh R, Mazoujian G, Goates J, Medeiros LJ, Weiss LM. Adrenal cortical tumors clinically mimicking pheochromocytoma. Am J Clin Pathol 1995;104:382-390.
  3. Barzon L, Boscaro M. Diagnosis and management of adrenal incidentalomas. J Urol 2000;163:398-407. https://doi.org/10.1016/S0022-5347(05)67888-3
  4. Ross NS, Aron DC. Hormonal evaluation of the patient with an incidentally discovered adrenal mass. N Engl J Med 1990;323:1401-1405. https://doi.org/10.1056/NEJM199011153232007
  5. Simon S, Totsch M, Schmidlin F, Iselin CE, Meier CA. Adrenal cortical phaeochromocytoma: a case report of a rare entity. Exp Clin Endocrinol Diabetes 2003;111:111-114. https://doi.org/10.1055/s-2003-39239
  6. Kim JC, Yoon JH, Jegal YJ. A clinical analysis of pheochromocytoma. J Korean Surg Soc 1997;52:662-670.
  7. Ivsic T, Komorowski RA, Sudakoff GS, Wilson SD, Datta MW. Adrenal cortical adenoma with adrenalin-type neurosecretory granules clinically mimicking a pheochromocytoma. Arch Pathol Lab Med 2002;126:1530-1533.
  8. Eranko O, Hanninen L. Electron microscopic observations on the adrenal medulla of the rat. Acta Pathol Microbiol Scand 1960;50:126-132.
  9. Kovacs K, Horvath E. Ultrastructural features of corticomedullary cells in a human adrenocortical adenoma and in rat adrenal cortex. Anat Anz 1973;134:387-393.
  10. Chung MK, Kim YC, Jeon EK. A case of adrenocortical adenoma clinically mimicking pheochromocytoma. Korean J Med 2008;75:479-483.