Korean Circulation Journal

  • 제41권4호
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  • Pages.198-202
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  • 2011
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  • 1738-5520(pISSN)
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  • 1738-5555(eISSN)
대한심장학회 (The Korean Society of Cardiology)
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Relationship Between Plasma Adiponectin, Retinol-Binding Protein 4 and Uric Acid in Hypertensive Patients With Metabolic Syndrome

  • Park, Chan-Seok (Department of Cardiology, College of Medicine, The Catholic University of Korea, Bucheon St. Mary' Hospital) ;
  • Ihm, Sang-Hyun (Department of Cardiology, College of Medicine, The Catholic University of Korea, Bucheon St. Mary' Hospital) ;
  • Park, Hun-Jun (Department of Cardiology, College of Medicine, The Catholic University of Korea, Bucheon St. Mary' Hospital) ;
  • Shin, Woo-Seung (Department of Cardiology, College of Medicine, The Catholic University of Korea, Bucheon St. Mary' Hospital) ;
  • Kim, Pum-Jun (Department of Cardiology, College of Medicine, The Catholic University of Korea, Bucheon St. Mary' Hospital) ;
  • Chang, Ki-Yuk (Department of Cardiology, College of Medicine, The Catholic University of Korea, Bucheon St. Mary' Hospital) ;
  • Kim, Hee-Yeol (Department of Cardiology, College of Medicine, The Catholic University of Korea, Bucheon St. Mary' Hospital) ;
  • Youn, Ho-Joong (Department of Cardiology, College of Medicine, The Catholic University of Korea, Bucheon St. Mary' Hospital) ;
  • Chung, Wook-Sung (Department of Cardiology, College of Medicine, The Catholic University of Korea, Bucheon St. Mary' Hospital) ;
  • Seung, Ki-Bae (Department of Cardiology, College of Medicine, The Catholic University of Korea, Bucheon St. Mary' Hospital) ;
  • Kim, Jae-Hyung (Department of Cardiology, College of Medicine, The Catholic University of Korea, Bucheon St. Mary' Hospital)
  • 발행 : 2011.04.30
⟨ 이전 논문 다음 논문 ⟩

초록

Background and Objectives: Adipokines have been suggested for their potential use in tracking the clinical progress in the subjects with metabolic syndrome (MS). To investigate the relationship between the serum levels of adipokines {adiponectin and retinol-binding protein 4 (RBP4)} and the serum level of uric acid in hypertensive (HTN) patients with MS. Subjects and Methods: In this study, 38 totally untreated HTN patients were enrolled. Anthropometric measurements, blood pressure (BP) were taken in the 12 HTN patients without MS and the 26 HTN patients with MS. Fasting blood samples were collected for measurement of adiponectin, RBP4, nitric oxide (NO), glucose, creatinine, uric acid, lipid profile and insulin. Results: The HTN with MS group had significant higher values of body mass index, waist length, serum uric acid and triglyceride levels than the HTN without MS group. Compared to the HTN without MS group, the HTN with MS group showed significantly lower adiponectin (p=0.030), NO (p=0.003) and high density lipoprotein levels (p<0.001). Serum adiponectin levels negatively correlated with insulin level (R=-0.453, p=0.026) and uric acid level (R=-0.413, p=0.036), and serum RBP4 levels positively correlated with uric acid level (R=0.527, p=0.006) in the HTN with MS group. Multiple linear regression analysis using RBP4 and adiponectin levels as the dependent variables showed that uric acid level correlated with serum RBP4 level (p=0.046) and adiponectin level (p=0.044). Conclusion: The HTN with MS group showed a correlation with two types of adipokines (adiponectin, RBP4) and uric acid. Adiponectin, RBP4 and uric acid may be important components associated with MS, especially when associated with hypertension.

키워드

참고문헌

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피인용 문헌

  1. Uric acid upregulates the adiponectin-adiponectin receptor 1 pathway in renal proximal tubule epithelial cells vol.17, pp.3, 2018, https://doi.org/10.3892/mmr.2017.8315
  2. Components of metabolic syndrome in relation to plasma levels of retinol binding protein 4 (RBP4) in a cohort of people aged 65 years and older vol.41, pp.10, 2011, https://doi.org/10.1007/s40618-018-0856-6