YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Analysis of Bioconversion Compositions from Fermented Bojungikki-tangs

발효보중익기탕들의 생물전환성분 분석

  • Kim, Dong-Seon (Herbal Medicine Improvement Research Center, Korea Institute of Oriental Medicine) ;
  • Roh, Joo-Hwan (Herbal Medicine Improvement Research Center, Korea Institute of Oriental Medicine) ;
  • Cho, Chang-Won (Regional Food Industry Research Group, Korea Food Research Institute) ;
  • Ma, Jin-Yeul (Herbal Medicine Improvement Research Center, Korea Institute of Oriental Medicine)
  • 김동선 (한국한의학연구원 신한방제제연구센터) ;
  • 노주환 (한국한의학연구원 신한방제제연구센터) ;
  • 조장원 (한국식품연구원) ;
  • 마진열 (한국한의학연구원 신한방제제연구센터)
  • Received : 2011.09.01
  • Accepted : 2011.09.30
  • Published : 2011.10.31
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Abstract

Traditional herbal medicinal preparation Bojungikki-tang (BJT) is well-known herbal medicine used as tonic. We fermented Bojungikki-tang using nine lactic acid bacteria strains and discovered two remarkably increased compositions from the fermented BJTs using HPLC/DAD analysis. HPLC/DAD-guided fractionation of the increased compositions followed by structure identification using NMR and MS identified liquiritigenin and isoliquiritigenin. These bioconversion compositions were quantitatively analyzed using HPLC-DAD. Liquiritigenin contents were highest in BJTs fermented with L. amylophilus (1.91 mg/g) and L. fermentum (1.89 mg/g), which were increased by 20-fold compared to BJT (0.09 mg/g). Isoliquiritigenin contents were highest in BJTs in fermented with L. plantarum (0.19 mg/g) and L. fermentum (0.19 mg/g), which were increased by 19-fold compared to BJT (0.01 mg/g).

Keywords

References

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