Development and Reproduction (한국발생생물학회지:발생과생식)

The Korean Society of Developmental Biology (한국발생생물학회)
권호 표지

Production of Intracellular Calcium Oscillation by Phospholipase C Zeta Activation in Mammalian Eggs

  • Yoon, Sook-Young (Fertility Center of CHA Gangnam Medical Center, College of Medicine, CHA University) ;
  • Kang, Da-Won (Dept. of Physiology and Institute of Health Sciences, Gyeongsang National University)
  • Received : 2011.08.30
  • Accepted : 2011.09.21
  • Published : 2011.09.30
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Abstract

Egg activation is a crucial step that initiates embryo development upon breaking the meiotic arrest. In mammalian, egg activation is accomplished by fusion with sperm, which induces the repeated intracellular $Ca^{2+}$- increases ($[Ca^{2+}]_i$ oscillation). Researches in mammals support the view of the $[Ca^{2+}]_i$ oscillation and egg activation is triggered by a protein factor from sperm that causes $[Ca^{2+}]_i$ release from endoplasmic reticulum, intracellular $[Ca^{2+}]_i$ store, by persistently activation of phosphoinositide pathway. It represents that the sperm factor generates production of inositol trisphosphate ($IP_3$). Recently a sperm specific form of phospholipase C zeta, referred to as PLCZ was identified. In this paper, we confer the evidence that PLCZ represent the sperm factor that induces $[Ca^{2+}]_i$ oscillation and egg activation and discuss the correlation of PLCZ and infertility.

Keywords

References

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