Development and Reproduction (한국발생생물학회지:발생과생식)

The Korean Society of Developmental Biology (한국발생생물학회)
권호 표지

Change of X Chromosome Status during Development and Reprogramming

  • Jung, Yong-Wook (Dept. of Genetics, Yale Stem Cell Center, Yale School of Medicine) ;
  • Park, In-Hyun (Dept. of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University)
  • Received : 2011.08.04
  • Accepted : 2011.08.26
  • Published : 2011.09.30
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Abstract

X chromosome inactivation (XCI) is a process that enables mammalian females to ensure the dosage compensation for X-linked genes. Investigating the mechanism of XCI might provide deeper understandings of chromosomal silencing, epigenetic regulation of gene expressions, and even the course of evolution. Studies on mammalian XCI conducted with mice have revealed many fundamental findings on XCI. However, difference of murine and human XCI necessitates the further investigation in human XCI. Recent success in reprogramming of differentiated cells into pluripotent stem cells showed the reversibility of XCI in vitro, X chromosome reactivation (XCR), which provides another tool to study the change in X chromosome status. This review summarizes the current knowledge of XCI during early embryonic development and describes recent achievements in studies of XCI in reprogramming process.

Keywords

References

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