Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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Effectiveness of autogenous tooth bone used as a graft material for regeneration of bone in miniature pig

미니피그에서 자가치아뼈 이식의 골형성 효과에 대한 연구

  • Jeong, Hye-Rin (Department of Oral & Maxillofacial Surgery, Dong Kang Medical Center) ;
  • Hwang, Ju-Hong (Department of Dentistry, Ajou University School of Medicine) ;
  • Lee, Jeong-Keun (Department of Dentistry, Ajou University School of Medicine)
  • 정혜린 (동강병원 구강악안면외과) ;
  • 황주홍 (아주대학교 의과대학 치과학교실) ;
  • 이정근 (아주대학교 의과대학 치과학교실)
  • Received : 2011.06.01
  • Accepted : 2011.09.29
  • Published : 2011.10.31
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Abstract

Introduction: This study examined the effect of autogenous tooth bone used as a graft material for bone regeneration in an artificial bony defect of minipigs. Materials and Methods: Four healthy minipigs, weighing approximately 35-40 kg, were used. Four standardized artificial two-walled bony defects, 5 mm in length and depth, were made on the bilateral partial edentulous alveolar ridge on the mandible of minipigs, and autogenous tooth bone was augmented in the right side as the experimental group. On the other hand, only alloplastic bone graft material HA was grafted with the same size and manner in the left side as the control group. All minipigs were sacrificed at 4 weeks after a bone graft and evaluated histologically by Haematoxylin-eosin staining. The specimens were also evaluated semi-quantitatively via a histomorphometric study. The percentage of new bone over the total area was evaluated using digital software for an area calculation. Results: All specimens were available but one in the left side (control group) and two in the right side (experimental group) were missing during specimen preparation. The amount of bone formation and remodeling were higher in all experimental groups than the control. The mean percentage area for new bone in the experimental and control groups was $43.74{\pm}11.96%$ and $30.79{\pm}2.93%$, respectively. Conclusion: Autogenous tooth bone is a good alternative to autogenous bone with the possible clinical feasibility of an autogenous tooth bone graft in the reconstruction of bony defects.

Keywords

References

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