Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Rapid One-pot, Four Component Synthesis of Pyranopyrazoles Using Heteropolyacid Under Solvent-free Condition

  • Chavan, Hemant V. (Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University) ;
  • Babar, Santosh B. (Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University) ;
  • Hoval, Rahul U. (Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University) ;
  • Bandgar, Babasaheb P. (Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University)
  • Received : 2011.08.26
  • Accepted : 2011.09.11
  • Published : 2011.11.20
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Abstract

A series of pyranopyrazoles, was efficiently synthesized via one-pot, four component reaction of ethyl acetoacetate, hydrazine hydrate, aldehydes and malononitrile in the presence of catalytic amount silicotungstic acid under solvent free condition. NOE experiments confirmed that the product exist exclusively in the 2H form. The present protocol offers the advantages of clean reaction, short reaction time, high yield, easy purification and economic availability of the catalyst.

Keywords

References

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