The Korean Journal of Mycology (한국균학회지)

The Korean Society of Mycology (한국균학회)
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Physiological Activities of Hot Water Extract and Solvent Fractions of Pleurotus ferulea

아위버섯 열수추출물 및 유기용매 분획물의 생리활성 효과

  • Kim, Jun-Ho (Department of Fine Chemistry and New Materials, Sangji University)
  • 김준호 (상지대학교 이공과대학 정밀화학신소재학과)
  • Received : 2011.10.14
  • Accepted : 2011.11.09
  • Published : 2011.12.01
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Abstract

To investigate the physiological activities of hot water extract and solvent fractions isolated from Pleurotus ferulea, antioxidative, fibrinolytic, thrombin inhibitory, and ${\alpha}$-glucosidase inhibitory activities were examined. Pleurotus ferulea, hot water extract was fractionated into hexane, chloroform, ethyl acetate, butanol and water fraction. Each of these was assayed individually. The antioxidative activities of ethyl acetate and butanol fractions were 86.79% and 87.82%, respectively. Using the fibrin plate method, only the ethyl acetate fraction showed a plasmin activity of 0.08 units/ml. Thrombin inhibitory activities of chloroform and ethyl acetate fractions were 74.90% and 71.08%, respectively. In the ${\alpha}$-glucosidase inhibitory activity test, butanol fraction showed the highest activity at 49.67%. From the above results, we anticipate that solvent fractions of Pleurotus ferulea can be used as a materials for the development of biofunctional foods for cardiovascular diseases.

아위버섯으로부터 성인병 치료와 예방 관련된 생리활성물질을 확인하고 이 물질의 추출을 위한 최적 조건을 확립하기위해 아위버섯 열수추출물과 유기용매 분획물을 사용하여 성인병 관련 생리활성을 측정하였다. 아위버섯 열수추출액에서는 작은 항산화효과. 트롬빈저해효과, 혈당강하효과가 확인되었지만 혈전용해효과는 나타나지 않았다. 그러나 에틸아세테이트 분획물과 부탄올 분획물에서 86.79%와 87.82%의 높은 항산화효과가 확인 되었으며, 에틸아세테이트 분획물에서 0.08 plasmin unit의 작은 혈전용해활성을 확인할 수 있었다. 클로로포름 분획물과 에틸아세테이트 분획물에서 74.90%와 71.88%의 높은 트롬빈저해효과와 함께 부탄올 분획물에서 49.67%의 혈당강하효과를 확인하였다. 따라서 아위버섯의 에틸아세테이트 분획물과 부탄올 분획물은 혈관계 질환을 위한 기능성 식품의 개발에 이용할 수 있을 것으로 판단된다.

Keywords

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