Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
권호 표지

Toxicity study of Wollastonite to the Respiratory Systems in Sprague-Dawely Rats

랫드에 투여된 규회석이 호흡기계에 미치는 영향 연구

  • Chung, Yong-Hyun (Chemical Safety and Health Research Center, Occupational Safety & Health Research Institute) ;
  • Han, Jeong-Hee (Chemical Safety and Health Research Center, Occupational Safety & Health Research Institute) ;
  • Kang, Min-Gu (Chemical Safety and Health Research Center, Occupational Safety & Health Research Institute) ;
  • Lee, Sung-Bae (Chemical Safety and Health Research Center, Occupational Safety & Health Research Institute) ;
  • Kim, Jong-Kyu (Chemical Safety and Health Research Center, Occupational Safety & Health Research Institute) ;
  • Kim, Hyeon-Yeong (Chemical Safety and Health Research Center, Occupational Safety & Health Research Institute) ;
  • Yang, Jung-Sun (Chemical Safety and Health Research Center, Occupational Safety & Health Research Institute)
  • 정용현 (산업안전보건연구원 화학물질안전보건센터) ;
  • 한정희 (산업안전보건연구원 화학물질안전보건센터) ;
  • 강민구 (산업안전보건연구원 화학물질안전보건센터) ;
  • 이성배 (산업안전보건연구원 화학물질안전보건센터) ;
  • 김종규 (산업안전보건연구원 화학물질안전보건센터) ;
  • 김현영 (산업안전보건연구원 화학물질안전보건센터) ;
  • 양정선 (산업안전보건연구원 화학물질안전보건센터)
  • Received : 2010.03.11
  • Accepted : 2010.10.18
  • Published : 2010.12.31
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Abstract

Occupational exposure to wollastonite can occur during its mining, processing and using. Wollastonite was analyzed for its physicochemical properties by transmission electron microscope and scanning electron microscope equipped with energy dispersive X-ray spectrometer. Wollastonite fibers were 3.3${\mu}m$ in diameter(av.) and were 30.5${\mu}m$ in length(av.). The atomic composition of wollastonite was Si 56.41% and Ca 43.59%. Respiratory toxicity of wollastonite has been studied in term sequential in Sprague-Dawely rats. UICC chrysotile (average diameter 0.03${\mu}m$, average length 2.93${\mu}m$) was applied as the positive control. The effects of 2mg wollastonite on respiratory system and pathological changes were evaluated after 1, 4, 8, 12 weeks instilled into rat lungs. Inflammation response broke out from 1 week after instilled with wollastonite and the pathological examination further showed increased legions of granulomatous inflammation after 4 weeks, but decreased granulomatous inflammation after 8 weeks, whereas chrysotile induced progressive interstitial granulomatous inflammation and fibrosis as a function of time.

Keywords

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