Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Cellular Density Evaluation for Malignant Lymphoma Using Equivalent Cross-Relaxation Rate Imaging - Initial Experience

  • Nishiofuku, Hideyuki (Department of Radiology, Nara Medical University) ;
  • Matsushima, Shigeru (Department of Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital) ;
  • Inaba, Yoshitaka (Department of Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital) ;
  • Yamaura, Hidekazu (Department of Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital) ;
  • Sato, Yozo (Department of Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital) ;
  • Morishima, Yasuo (Department of Hematology and Cell Therapy, Aichi Cancer Center Hospital) ;
  • Kichikawa, Kimihiko (Department of Radiology, Nara Medical University)
  • Received : 2009.06.30
  • Accepted : 2010.01.04
  • Published : 2010.06.01
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Abstract

Objective: Equivalent cross-relaxation rate (ECR) imaging is an MRI technique used to evaluate quantitatively a change in the protein-water interaction. We aimed to evaluate retrospectively the usefulness of ECR imaging for the histologic classification of malignant lymphoma (ML). Materials and Methods: Institutional Review Board approval was obtained and all patients provided informed consent. The study subjects included 15 patients with untreated ML who were histologically diagnosed with follicular lymphoma (FL; n = 8) or diffuse large B-cell lymphoma (DLBCL; n = 7). All patients underwent ECR imaging and the offset frequency was set at 7 ppm. Results: The median ECR values were 71% (range; 60.7 to 75.5) in FL and 54% (50.8 to 59.4) in DLBCL (p = 0.001). The median cellular density was $1.5{\pm}0.17{\times}10^6/mm^2$ in FL and $1.0{\pm}0.70{\times}10^6/mm^2$ in DLBCL (p = 0.001). The correlation coefficient between the ECR values and cellular density in ML was 0.88 (p = 0.001). In FL and DLBCL, assuming ECR value cut-off points of 60%, both sensitivity and specificity were 100%. Conclusion: A strong correlation between ECR and cellular density in ML is demonstrated and the ECR may be a useful technique to differentiate between FL and DLBCL.

Keywords

References

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