The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
권호 표지

A case of adrenocortical adenoma with primary hyperaldosteronism and subclinical Cushing's syndrome

원발성 고알도스테론혈증과 동반된 잠복성 쿠싱증후군 1예

  • Hwang, Byung-Hee (Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine) ;
  • Yu, Ji-Youn (Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine) ;
  • Jung, Jin-Hwan (Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine) ;
  • Kim, Sung-Rae (Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine) ;
  • Yoo, Soon-Jib (Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine) ;
  • Kang, Sung-Koo (Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine) ;
  • Lee, Seong-Su (Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine)
  • 황병희 (가톨릭대학교 의과대학 내과학교실) ;
  • 유지연 (가톨릭대학교 의과대학 내과학교실) ;
  • 정진환 (가톨릭대학교 의과대학 내과학교실) ;
  • 김성래 (가톨릭대학교 의과대학 내과학교실) ;
  • 유순집 (가톨릭대학교 의과대학 내과학교실) ;
  • 강성구 (가톨릭대학교 의과대학 내과학교실) ;
  • 이성수 (가톨릭대학교 의과대학 내과학교실)
  • Received : 2009.07.01
  • Accepted : 2009.10.05
  • Published : 2010.09.01
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Abstract

Cases of combined primary hyperaldosteronism and subclinical Cushing's syndrome are extremely rare. We identified a left adrenocortical tumor in a 41-year-old woman by computed tomography (CT) during an evaluation for hypokalemia and hypertension. Hormonal assessment demonstrated normal aldosterone concentrations, low plasma renin activity, an increased aldosterone/renin ratio, and normal serum cortisol levels. Selective adrenal venous sampling for the determination of aldosterone concentrations showed an overfunctioning left adrenal gland. Dexamethasone (overnight 1mg, 2 mg, 8 mg) suppression tests showed insuppressible cortisol. We diagnosed the patient as having an aldosterone-producing adrenal adenoma associated with subclinical Cushing's syndrome.

원발성 고알도스테론혈증과 잠복성 쿠싱 증후군을 동시에 보이는 부신피질샘종을 진단하였던 예는 극히 드물다. 저자들은 고혈압 및 저칼륨혈증에 의해 야기된 증상을 주소로 내원한 41세 여자에게서 원발성 고알도스테론혈증을 시사하는 검사 소견이 있어 이를 평가하던 중, 원발성 고알도스테론혈증과 잠복성 쿠싱 증후군을 동시에 보이는 부신피질 샘종 1예를 경험하였기에 문헌고찰과 함께 보고한다.

Keywords

References

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