Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Anti-Cancer Activity of T-Type Calcium Channel Blocker In Vivo

  • Park, Hang-Ah (Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University) ;
  • Jung, Soo-Yeon (Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University) ;
  • Lee, So-Hyung (Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University) ;
  • Kang, Han-Byul (Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University) ;
  • Min, Min-Sik (Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University) ;
  • Kim, Jung-Ahn (Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University) ;
  • Choo, Dong-Joon (Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University) ;
  • Oh, Chun-Rim (DongWoo Syntech Co., Ltd.) ;
  • Kim, Young-Deuk (DongWoo Syntech Co., Ltd.) ;
  • Lee, Kyung-Tae (Kyung Hee East-West Pharmaceutical Research Institute and Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University) ;
  • Lee, Jae-Yeol (Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University)
  • Received : 2010.08.02
  • Accepted : 2010.09.15
  • Published : 2010.11.20
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Abstract

3,4-Dihydroquinazoline 1 as T-type calcium channel blocker was in vivo evaluated against A549 xenograft in BALB/c-nu Slc mice, which exhibited 54% tumor growth inhibition through oral administration of 8 mg/kg of body weight and was slightly less active than doxorubicin (68%). In addition, this compound was also profiled for its acute toxicity to ICR mice to afford oral $LD_{50}$ value of 1,038 mg/kg of body weight.

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