Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis and Anti-HIV Activity of Novel 4'-Ethyl-5'-norcarbocyclic Adenosine Phosphonic Acid Analogues

  • Yoo, Jin-Cheol (BK-21 Project Team, College of Pharmacy, Chosun University) ;
  • Li, Hua (BK-21 Project Team, College of Pharmacy, Chosun University) ;
  • Lee, Won-Jae (BK-21 Project Team, College of Pharmacy, Chosun University) ;
  • Hong, Joon-Hee (BK-21 Project Team, College of Pharmacy, Chosun University)
  • Received : 2010.07.20
  • Accepted : 2010.09.15
  • Published : 2010.11.20
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Abstract

Novel 4'-ethyl-5'-norcarbocyclic adenosine phosphonic acid analogues were synthesized from propionaldehyde 5 through a de novo acyclic synthetic route using reiterative Grignard additions and ring-closing metathesis (RCM) as key reactions. The synthesized nucleoside phosphonic acids analogues 17, 18, 19, and 21 were subjected to antiviral screening against human immunodeficiency virus.

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References

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