Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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Stem Cell Based Strategies for the Treatment of Degenerative Retinal Diseases

망막변성질환에서의 줄기세포 기반치료

  • Park, Jung-Hyun (Department of Ophthalmology, Seoul Paik Hospital, Inje University) ;
  • Ku, Seung-Yup (Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University) ;
  • Cho, Myung-Soo (Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University) ;
  • Lee, Hak-Sup (Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University) ;
  • Choi, Young-Min (Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University) ;
  • Moon, Shin-Yong (Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University) ;
  • Yu, Hyeong-Gon (Department of Ophthalmology, Seoul National University College of Medicine)
  • 박정현 (인제대학교 서울백병원 안과) ;
  • 구승엽 (서울대학교 의학연구원 인구의학연구소) ;
  • 조명수 (서울대학교 의학연구원 인구의학연구소) ;
  • 이학섭 (서울대학교 의학연구원 인구의학연구소) ;
  • 최영민 (서울대학교 의학연구원 인구의학연구소) ;
  • 문신용 (서울대학교 의학연구원 인구의학연구소) ;
  • 유형곤 (서울대학교 의과대학 안과학교실)
  • Received : 2010.05.07
  • Accepted : 2010.08.12
  • Published : 2010.09.30
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Abstract

Stem-cell therapy has the potential to improve vision in patients with untreatable retinal disease. Various types of cell source including fetal, embryonic and adult stem cells, intrinsic and extrinsic factors for differentiation into retinal progenitors and transplantation mode were discussed in this review. Experimental approaches have successfully induced photoreceptor precursor cells and retinal pigment epithelium. Stem-cell-based therapy is a promising treatment to restore vision in patients with retinal disease, in spite of the challenges.

망막 질환에서의 줄기세포 치료는 이전까지 치료가 불가능하다고 여겨졌던 환자들에서 시력을 향상시킬 수 있는 가능성 때문에 주목 받고 있다. 본문에서는 망막 전구세포의 분화를 위해 사용되는 태아 줄기세포, 배아줄기세포 및 성체줄기세포 등 다양한 세포 종류와, 내인적, 외인적 인자 및 이식 방법에 대해 논의하였다. 망막색소상피세포뿐만 아니라 시각세포 전구체로 성공적으로 분화시킨 실험적 연구가 보고되고 있다. 줄기세포기반치료는 아직 한계가 있지만 망막 질환 환자에서 시력을 회복하기 위한 보다 근본적인 치료 방법으로 기대되고 있다.

Keywords

References

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