Journal of the East Asian Society of Dietary Life (동아시아식생활학회지)

The East Asian Society of Dietary Life (동아시아식생활학회)
권호 표지

Effects of Caffeine Supplementation on Lipid Concentrations of Serum and Liver in Ovariectomized Rats

난소 절제 흰쥐에서 카페인 첨가가 혈액과 간 지질 농도에 미치는 영향

  • Choi, Mi-Ja (Dept. of Food & Nutrition, Keimyung University) ;
  • Jo, Hyun-Ju (Dept. of Medicinal Food & Health, World Cyber College)
  • 최미자 (계명대학교 식품영양학과) ;
  • 조현주 (세계사이버대학 약용건강식품과)
  • Received : 2010.03.22
  • Accepted : 2010.06.16
  • Published : 2010.06.30
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Abstract

The purpose of this study was to examine the impact of caffeine on lipid concentrations in ovariectomized rats. Forty-four rats (75${\pm}$5 g) were randomly divided into ovariectomy(ovx) and sham groups, each of which were randomly divided into two subgroups that were fed the control diet or a caffeine-supplemented diet (0.03%/diet). The experimental groups were classified into 1) sham-control, 2) sham-caffeine, 3) ovx-control and 4) ovx-caffeine groups. All rats had been fed on experimental diet and deionized water ad libitum for 6 weeks. Triglyceride concentration and total cholesterol were measured in serum and liver. Serum HDL-cholesterol was measured. Serum LDL-cholesterol and atherogenic index were calculated. Weight gain and food efficiency ratio were higher in ovx groups than in sham groups (p<0.05). Caffeine intake did not affect weight gain and food efficiency ratio. Mean food intake was significantly increased in ovx-caffeine group than other three groups. There were no significant differences in serum triglyceride, total cholesterol, HDL-cholesterol, LDL-cholesterol and atherogenic index between the control diet group and caffeine diet group. In addition, hepatic triglyceride and cholesterol level was unaffected by caffeine intake or ovariectomy. Therefore, we suggest that caffeine (0.03%/diet) intake may not have adverse effects on serum lipid level in ovariectomized rats.

Keywords

References

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