Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제36권3호
  • /
  • Pages.206-210
  • /
  • 2010
  • /
  • 2234-7550(pISSN)
  • /
  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
권호 표지
DOI QR코드

DOI QR Code

Bisphosphonate-related osteonecrosis of jaw의 치료에 대한 고찰

Consideration for treatment of bisphosphonate-related osteonecrosis of the jaw

  • 유경하 (인제대학교 상계백병원 구강악안면외과학교실) ;
  • 윤규호 (인제대학교 상계백병원 구강악안면외과학교실) ;
  • 배정호 (인제대학교 상계백병원 구강악안면외과학교실) ;
  • 박재안 (인제대학교 상계백병원 구강악안면외과학교실) ;
  • 박군찬 (인제대학교 상계백병원 구강악안면외과학교실) ;
  • 신재명 (인제대학교 일산백병원 구강악안면외과학교실) ;
  • 백지선 (인제대학교 일산백병원 구강악안면외과학교실) ;
  • 정정권 (인제대학교 상계백병원 구강악안면외과학교실)
  • You, Kyung-Ha (Department of Oral and Maxillofacial Surgery, Inje University Sanggye Paik Hospital) ;
  • Yoon, Kyu-Ho (Department of Oral and Maxillofacial Surgery, Inje University Sanggye Paik Hospital) ;
  • Bae, Jung-Ho (Department of Oral and Maxillofacial Surgery, Inje University Sanggye Paik Hospital) ;
  • Park, Jae-An (Department of Oral and Maxillofacial Surgery, Inje University Sanggye Paik Hospital) ;
  • Park, Gun-Chan (Department of Oral and Maxillofacial Surgery, Inje University Sanggye Paik Hospital) ;
  • Shin, Jae-Myung (Department of Oral and Maxillofacial Surgery, Inje University Ilsan Paik Hospital) ;
  • Baik, Jee-Seon (Department of Oral and Maxillofacial Surgery, Inje University Ilsan Paik Hospital) ;
  • Cheong, Jeong-Kwon (Department of Oral and Maxillofacial Surgery, Inje University Sanggye Paik Hospital)
  • 투고 : 2010.03.22
  • 심사 : 2010.05.20
  • 발행 : 2010.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Bisphosphonates are widely used to treat osteoporosis, hypercalcemia of malignant tumor. Despite their clinical benefit, bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a newly documented complication to patients receiving these drugs and first recognized by Marx in 2003. Thus, consideration of prevention and needs regarding unequivocal treatment regimen have emerged. Recently, several authors emphasized reports on appropriate clinical availability of surgical approach. It serves to concern about guideline for surgical and conservative treatment modalities. So, it is the purpose of this paper to review the current literatures about treatment regimens of BRONJ.

키워드

참고문헌

  1. Owens G, Jackson R, Lewiecki EM. An integrated approach: bisphosphonate management for treatment of osteoporosis. Am J Manag Care 2007;13 Suppl 11:S290-308.
  2. Marx RE. Pamidronate (Aredia) and zolendronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 2003;61:1115-7. https://doi.org/10.1016/S0278-2391(03)00720-1
  3. Ruggiero SL. Bisphosphonate-related osteonecrosis of the jaw (BRONJ): initial discovery and subsequent development. J Oral Maxillofac Surg 2009;67(5 Suppl 1):13-8.
  4. Ruggiero SL, Drew SJ. Osteonecrosis of the jaws and bisphosphonate therapy. J Dent Res 2007;86:1013-21. https://doi.org/10.1177/154405910708601101
  5. Mavrokokki T, Cheng A, Stein B, Goss A. Nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in Australia. J Oral Maxillofac Surg 2007;65:415-23. https://doi.org/10.1016/j.joms.2006.10.061
  6. Advisory Task Force on Bisphosphonate-Related Ostenonecrosis of the Jaws, American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg 2007;65:369-76. https://doi.org/10.1016/j.joms.2006.11.003
  7. The Korean Endocrine Society, the Korean Society of Bone Metabolism, the Korean Society of Osteoporosis, the Korean Association of Oral and Maxillofacial Surgeons. Bisphosphonate related osteonecrosis of the jaw (BRONJ)-position statement of Korea. J Korean Endocr Soc 2009;24:227-30. https://doi.org/10.3803/jkes.2009.24.4.227
  8. Ohe JY, Kwon YD, Kim YG, Lee BS. Yoon BW, Choi BJ. Features of histologic and radiographic findings in bisphosphonate- related osteonecrosis of jaw-clinical review. J Korean Assoc Oral Maxillofac Surg 2008;34:550-4.
  9. Ruggiero SL, Dodson TB, Assael LA, Landesberg R, Marx RE, Mehrotra B; American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws-2009 update. J Oral Maxillofac Surg 2009;67(5 Suppl):2-12. https://doi.org/10.1016/j.joms.2009.01.009
  10. Kwon YD, Yoon BW, Walter C. Bispohspohonate, is it an emerging risk factor in oral surgery? J Korean Assoc Maxillofac Plast Reconstr Surg 2007;29:456-62.
  11. Siddiqi A, Payne AG, Zafar S. Bisphosphonate-induced osteonecrosis of the jaw: a medical enigma? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108:e1-8. https://doi.org/10.1016/j.tripleo.2009.04.013
  12. Hansen T, Kunkel M, Weber A, James Kirkpatrick C. Osteonecrosis of the jaws in patients treated with bisphosphonates- histomorphologic analysis in comparison with infected osteonecrosis. J Oral Pathol Med 2006;35:155-60. https://doi.org/10.1111/j.1600-0714.2006.00391.x
  13. Migliorati CA, Casiglia J, Epstein J, Jacobsen PL, Siegel MA, Woo SB. Managing the care of patients with bisphosphonate-associated osteonecrosis: an American Academy of Oral Medicine position paper. J Am Dent Assoc 2005;136:1658-68.
  14. Sawatari Y, Marx RE. Bisphosphonates and bisphosphonate induced osteonecrosis. Oral Maxillofac Surg Clin North Am 2007;19:487-98. https://doi.org/10.1016/j.coms.2007.07.003
  15. Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff SL. Osteonecrosis of the jaws associated with the use of bisphosphonates: a reviews of 63 cases. J Oral Maxillofac Surg 2004;62: 527-34. https://doi.org/10.1016/j.joms.2004.02.004
  16. Chaudhry AN, Ruggiero SL. Osteonecrosis and bisphosphonates in oral and maxillofacial surgery. Oral Maxillofac Surg Clin North Am 2007;19:199-206. https://doi.org/10.1016/j.coms.2007.01.005
  17. Marx RE, Sawatari Y, Fortin M, Broumand V. Bisphosphonateinduced exposed bone (osteonecrosis/osteopetrosis)of the jaws: risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg 2005;63:1567-75. https://doi.org/10.1016/j.joms.2005.07.010
  18. Lazarovici TS, Yahalom R, Taicher S, Elad S, Hardan I, Yarom N. Bisphosphonate-related osteonecrosis of the jaws: a singlecenter study of 101 patients. J Oral Maxillofac Surg 2009;67: 850-5. https://doi.org/10.1016/j.joms.2008.11.015
  19. Thumbigere-Math V, Sabino MC, Gopalakrishnan R, Huckabay S, Dudek AZ, Basu S, et al. Bisphosphonate-related osteonecrosis of the jaw: clinical features, risk factors, management, and treatment outcomes of 26 patients. J Oral Maxillofac Surg 2009; 67:1904-13. https://doi.org/10.1016/j.joms.2009.04.051
  20. Ruggiero SL, Fantasia J, Carlson E. Bisphosphonate-related osteonecrosis of the jaw: background and guidelines for diagnosis, staging and management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;102:433-41. https://doi.org/10.1016/j.tripleo.2006.06.004
  21. Tirelli G, Biasotto M, Chiandussi S, Dore F, de Nardi E, di Lenarda R, et al. Bisphosphonate-associated osteonecrosis of the jaws: the limits of a conservative approach. Head Neck 2009; 31:1249-54. https://doi.org/10.1002/hed.21019
  22. Stanton DC, Balasanian E. Outcome of surgical management of bisphosphonate-related osteonecrosis of the jaws: review of 33 surgical cases. J Oral Maxillofac Surg 2009;67:943-50. https://doi.org/10.1016/j.joms.2008.12.057
  23. Arce K, Assael LA, Weissman JL, Makiewicz MR. Imaging findings in bisphosphonate-related osteonecrosis of jaws. J Oral Maxillofac Surg 2009;67(5 Suppl):75-84. https://doi.org/10.1016/j.joms.2008.12.002
  24. Wutzl A, Biedermann E, Wanschitz F, Seemann R, Klug C, Baumann A, et al. Treatement results of bisphosphonate-related osteonecrosis of the jaws. Head Neck 2008;30:1224-30. https://doi.org/10.1002/hed.20864
  25. Carlson ER, Basile JD. The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg 2009;67(5 Suppl):85-95. https://doi.org/10.1016/j.joms.2009.01.006
  26. Freiberger JJ. Utility of hyperbaric oxygen in treatment of bisphosphonate- related osteonecrosis of the jaws. J Oral Maxillofac Surg 2009;67(5 Suppl):96-106. https://doi.org/10.1016/j.joms.2008.12.003
  27. Mignogna MD, Fedele S, Lo Russo L, Ciccarelli R, Lo Muzio L. Case 2. Osteoenecrosis of the jaws associated with bisphosphonate therapy. J Clin Oncol 2006;24:1475-7. https://doi.org/10.1200/JCO.2005.01.7756
  28. Magopoulos C, Karakinaris G, Telioudis Z, Vahtsevanos K, Dimitrakopoulos l, Antoniadis K, et al. Osteoenecrosis of the jaws due to bisphosphonate use. A review of 60 cases and treatment proposals. Am J Otolaryngol 2007;28:158-63. https://doi.org/10.1016/j.amjoto.2006.08.004
  29. Nastro E, Musolino C, Allegra A, Oteri G, Cicciu M, Alonci A, et al. Bisphosphonate-associated osteonecrosis of the jaw in patients with multiple myeloma and breast cancer. Acta Haematol 2007;117:181-7. https://doi.org/10.1159/000097876
  30. Black DM, Schwartz AV, Ensrud KE, Cauley JA, Levis S, Quandt SA, et al. Effects of continuing or stopping alendronate after 5 years of treatment: the fracture intervention trial long-term extension(FLEX): a randomized trial. JAMA 2006;296:2927-38. https://doi.org/10.1001/jama.296.24.2927
  31. Khosla S, Burr D, Cauley J, Dempster DW, Ebeling PR, Felsenberg D, et al.; American Society for Bone and Mineral Research. Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 2007;22:1479-91. https://doi.org/10.1359/jbmr.0707onj
  32. Assael LA. Oral bisphosphonates as a cause of bisphosphonaterelated osteonecrosis of the jaws: clinical findings, assessment of risks, and preventive strategies. J Oral Maxillofac Surg 2009; 67(5 Suppl):35-43. https://doi.org/10.1016/j.joms.2009.01.003
  33. Dodson TB. Intravenous bisphosphonate therapy and bisphosphonate- related osteonecrosis of the jaws. J Oral Maxillofac Surg 2009;67(5 Suppl):44-52. https://doi.org/10.1016/j.joms.2008.12.004

피인용 문헌

  1. 비스포스포네이트 관련 악골괴사(BRONJ)의 병기 2기에서의 외과적, 보존적 치료에 대한 비교 연구 vol.35, pp.5, 2010, https://doi.org/10.14402/jkamprs.2013.35.5.302