Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Effect of White, Taegeuk, and Red Ginseng Root Extracts on Insulin-Stimulated Glucose Uptake in Muscle Cells and Proliferation of β-cells

  • Cha, Ji-Young (Laboratory of Cell Metabolism and Gene Regulation, Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science) ;
  • Park, Eun-Young (Laboratory of Beta Cell Biology and Autoimmunity, Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science) ;
  • Kim, Ha-Jung (Laboratory of Cell Metabolism and Gene Regulation, Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science) ;
  • Park, Sang-Un (College of Agriculture & Life Science, Chungnam National University) ;
  • Nam, Ki-Yeul (College of Agriculture & Life Science, Chungnam National University) ;
  • Choi, Jae-Eul (College of Agriculture & Life Science, Chungnam National University) ;
  • Jun, Hee-Sook (Laboratory of Beta Cell Biology and Autoimmunity, Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science)
  • Received : 2010.04.19
  • Accepted : 2010.06.25
  • Published : 2010.09.30
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Abstract

Recent studies have indicated that $\beta$-cell dysfunction and insulin resistance are important factors in the development of type 2 diabetes. The present study investigated the effect of extracts from different parts of white, Taegeuk, and red ginseng root on insulin-stimulated glucose uptake in muscle cells and proliferation of $\beta$-cells. Extracts of the fine roots of Taegeuk ginseng significantly enhanced glucose uptake compared with the control. White ginseng lateral root extracts enhanced insulin-induced glucose uptake. Proliferation of $\beta$-cells was significantly increased by Taegeuk ginseng main and lateral root extracts and by red ginseng lateral and fine root extracts. In conclusion, different root parts of white, Taegeuk, and red ginseng differentially affect glucose uptake and pancreatic $\beta$-cell proliferation.

Keywords

References

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